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Unravelling hepatitis C virus replication from genome to function

Author

Listed:
  • Brett D. Lindenbach

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Charles M. Rice

    (Center for the Study of Hepatitis C, The Rockefeller University)

Abstract

Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to dissect this pathogen has met with roadblocks that impeded progress. Its replication was restricted to humans or experimentally infected chimpanzees, and efficient growth of the virus in cell culture failed until very recently. Nevertheless hard-fought progress has been made and the first wave of antiviral drugs is entering clinical trials.

Suggested Citation

  • Brett D. Lindenbach & Charles M. Rice, 2005. "Unravelling hepatitis C virus replication from genome to function," Nature, Nature, vol. 436(7053), pages 933-938, August.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7053:d:10.1038_nature04077
    DOI: 10.1038/nature04077
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    Cited by:

    1. Qiu Pan & Yan Xie & Ying Zhang & Xinqi Guo & Jing Wang & Min Liu & Xiao-Lian Zhang, 2024. "EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Maureen J Donlin & Elena Lomonosova & Alexi Kiss & Xiaohong Cheng & Feng Cao & Teresa M Curto & Adrian Di Bisceglie & John E Tavis, 2014. "HCV Genome-Wide Genetic Analyses in Context of Disease Progression and Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-14, July.

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