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Mutations in a signalling pathway

Author

Listed:
  • D. Williams Parsons

    (The Johns Hopkins University Medical Institutions)

  • Tian-Li Wang

    (The Johns Hopkins University Medical Institutions)

  • Yardena Samuels

    (The Johns Hopkins University Medical Institutions)

  • Alberto Bardelli

    (The Johns Hopkins University Medical Institutions
    University of Torino Medical School
    FIRC Institute of Molecular Oncology)

  • Jordan M. Cummins

    (The Johns Hopkins University Medical Institutions)

  • Laura DeLong

    (The Johns Hopkins University Medical Institutions)

  • Natalie Silliman

    (The Johns Hopkins University Medical Institutions)

  • Janine Ptak

    (The Johns Hopkins University Medical Institutions)

  • Steve Szabo

    (The Johns Hopkins University Medical Institutions)

  • James K. V. Willson

    (Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center)

  • Sanford Markowitz

    (Howard Hughes Medical Institute and Ireland Cancer Center, University Hospitals of Cleveland and Case Western University)

  • Kenneth W. Kinzler

    (The Johns Hopkins University Medical Institutions)

  • Bert Vogelstein

    (The Johns Hopkins University Medical Institutions)

  • Christoph Lengauer

    (The Johns Hopkins University Medical Institutions)

  • Victor E. Velculescu

    (The Johns Hopkins University Medical Institutions)

Abstract

Protein kinases are enzymes that are important for controlling cellular growth and invasion1, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.

Suggested Citation

  • D. Williams Parsons & Tian-Li Wang & Yardena Samuels & Alberto Bardelli & Jordan M. Cummins & Laura DeLong & Natalie Silliman & Janine Ptak & Steve Szabo & James K. V. Willson & Sanford Markowitz & Ke, 2005. "Mutations in a signalling pathway," Nature, Nature, vol. 436(7052), pages 792-792, August.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7052:d:10.1038_436792a
    DOI: 10.1038/436792a
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    Cited by:

    1. Sol Efroni & Carl F Schaefer & Kenneth H Buetow, 2007. "Identification of Key Processes Underlying Cancer Phenotypes Using Biologic Pathway Analysis," PLOS ONE, Public Library of Science, vol. 2(5), pages 1-10, May.

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