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A possible unifying principle for mechanosensation

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  • Ching Kung

    (University of Wisconsin)

Abstract

Of Aristotle's five senses, we know that sight, smell and much of taste are initiated by ligands binding to G-protein-coupled receptors; however, the mechanical sensations of touch and hearing remain without a clear understanding of their molecular basis. Recently, the relevant force-transducing molecules—the mechanosensitive ion channels—have been identified. Such channel proteins purified from bacteria sense forces from the lipid bilayer in the absence of other proteins. Recent evidence has shown that lipids are also intimately involved in opening and closing the mechanosensitive channels of fungal, plant and animal species.

Suggested Citation

  • Ching Kung, 2005. "A possible unifying principle for mechanosensation," Nature, Nature, vol. 436(7051), pages 647-654, August.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7051:d:10.1038_nature03896
    DOI: 10.1038/nature03896
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    Cited by:

    1. Alexandre Pozza & François Giraud & Quentin Cece & Marina Casiraghi & Elodie Point & Marjorie Damian & Christel Le Bon & Karine Moncoq & Jean-Louis Banères & Ewen Lescop & Laurent J. Catoire, 2022. "Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Yuqi Qin & Daqi Yu & Dan Wu & Jiangqing Dong & William Thomas Li & Chang Ye & Kai Chit Cheung & Yingyi Zhang & Yun Xu & YongQiang Wang & Yun Stone Shi & Shangyu Dang, 2023. "Cryo-EM structure of TMEM63C suggests it functions as a monomer," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Ahmed Al-Ansi & Abdullah M. Al-Ansi & Ammar Muthanna & Ibrahim A. Elgendy & Andrey Koucheryavy, 2021. "Survey on Intelligence Edge Computing in 6G: Characteristics, Challenges, Potential Use Cases, and Market Drivers," Future Internet, MDPI, vol. 13(5), pages 1-23, April.
    4. Jonathan Mount & Grigory Maksaev & Brock T. Summers & James A. J. Fitzpatrick & Peng Yuan, 2022. "Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Ben Sorum & Trevor Docter & Vincent Panico & Robert A. Rietmeijer & Stephen G. Brohawn, 2024. "Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    6. Mees Muller & Kier Heeck & Coen P H Elemans, 2016. "Semicircular Canals Circumvent Brownian Motion Overload of Mechanoreceptor Hair Cells," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-15, July.

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