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T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand

Author

Listed:
  • Kaushik Choudhuri

    (University of Oxford)

  • David Wiseman

    (University of Oxford)

  • Marion H. Brown

    (University of Oxford)

  • Keith Gould

    (Imperial College London)

  • P. Anton van der Merwe

    (University of Oxford)

Abstract

T-cell receptor: small wonder The T cells patrol the body in search of unfamiliar molecules (antigens) that suggest the presence of harmful microorganisms. T-cell antigen receptors (TCRs) on the surface of T cells detect antigens presented on the surface of other cells by molecules of the MHC (major histocompatibility complex). Despite intensive study it is not known how TCR binding transmits a signal into the T-cell interior. New experiments suggest that the mechanism involves size-mediated segregation of the small TCR from the larger inhibitory molecules at the interface between the T cell and the cell that it is interacting with. The importance of the small size of the TCR-containing complex for TCR triggering raises the question of whether size has a role in signal transduction induced by other receptor–ligand interactions.

Suggested Citation

  • Kaushik Choudhuri & David Wiseman & Marion H. Brown & Keith Gould & P. Anton van der Merwe, 2005. "T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand," Nature, Nature, vol. 436(7050), pages 578-582, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7050:d:10.1038_nature03843
    DOI: 10.1038/nature03843
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    Cited by:

    1. Kai Liu & Brian Chu & Jay Newby & Elizabeth L Read & John Lowengrub & Jun Allard, 2019. "Hydrodynamics of transient cell-cell contact: The role of membrane permeability and active protrusion length," PLOS Computational Biology, Public Library of Science, vol. 15(4), pages 1-21, April.

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