IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v436y2005i7047d10.1038_nature03712.html
   My bibliography  Save this article

Angiotensin-converting enzyme 2 protects from severe acute lung failure

Author

Listed:
  • Yumiko Imai

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Keiji Kuba

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Shuan Rao

    (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Yi Huan

    (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Feng Guo

    (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Bin Guan

    (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Peng Yang

    (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Renu Sarao

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Teiji Wada

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Howard Leong-Poi

    (St. Michael's Hospital)

  • Michael A. Crackower

    (Merck Frosst Centre for Therapeutic Research)

  • Akiyoshi Fukamizu

    (University of Tsukuba)

  • Chi-Chung Hui

    (University of Toronto)

  • Lutz Hein

    (University of Freiburg)

  • Stefan Uhlig

    (Research Center Borstel)

  • Arthur S. Slutsky

    (University of Toronto, St. Michael's Hospital)

  • Chengyu Jiang

    (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Josef M. Penninger

    (IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

Abstract

Drug hope for SARS The SARS (severe acute respiratory syndrome) epidemic of 2003 caused almost 800 deaths, many of them due to acute respiratory distress syndrome (ARDS) as a complication. There are no effective drugs available for treating ARDS, but new work in mice suggests that ACE2 (angiotensin-converting enzyme 2) might be an option. ACE2 can protect mice from lung injury in an ARDS-like syndrome, whereas other components of the renin–angiotensin system for controlling blood pressure and salt balance actually make the condition worse. ACE2 is expressed in the healthy lung but downregulated by lung injury and it was shown recently (Nature 426, 450–454; 2003) to be a receptor for the SARS coronavirus.

Suggested Citation

  • Yumiko Imai & Keiji Kuba & Shuan Rao & Yi Huan & Feng Guo & Bin Guan & Peng Yang & Renu Sarao & Teiji Wada & Howard Leong-Poi & Michael A. Crackower & Akiyoshi Fukamizu & Chi-Chung Hui & Lutz Hein & S, 2005. "Angiotensin-converting enzyme 2 protects from severe acute lung failure," Nature, Nature, vol. 436(7047), pages 112-116, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7047:d:10.1038_nature03712
    DOI: 10.1038/nature03712
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature03712
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature03712?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tomokazu Yamaguchi & Midori Hoshizaki & Takafumi Minato & Satoru Nirasawa & Masamitsu N. Asaka & Mayumi Niiyama & Masaki Imai & Akihiko Uda & Jasper Fuk-Woo Chan & Saori Takahashi & Jianbo An & Akari , 2021. "ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Milad Haghani & Pegah Varamini, 2021. "Temporal evolution, most influential studies and sleeping beauties of the coronavirus literature," Scientometrics, Springer;Akadémiai Kiadó, vol. 126(8), pages 7005-7050, August.
    3. Jung-Hyun Kim & Jeeyoung Kim & Woo Jin Kim & Yung Hyun Choi & Se-Ran Yang & Seok-Ho Hong, 2020. "Diesel Particulate Matter 2.5 Induces Epithelial-to-Mesenchymal Transition and Upregulation of SARS-CoV-2 Receptor during Human Pluripotent Stem Cell-Derived Alveolar Organoid Development," IJERPH, MDPI, vol. 17(22), pages 1-15, November.
    4. Steven Andrew Baker & Shirley Kwok & Gerald J Berry & Thomas J Montine, 2021. "Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-17, February.
    5. Sara, Raisa & Radoias, Vlad & Kim, Younoh, 2024. "Hypertension effects of the COVID-19 lockdowns: Evidence from a repeated cross-sectional survey in Peru," Economics & Human Biology, Elsevier, vol. 52(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:436:y:2005:i:7047:d:10.1038_nature03712. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.