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Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

Author

Listed:
  • U. Maskos

    (Institut Pasteur)

  • B. E. Molles

    (Institut Pasteur)

  • S. Pons

    (Institut Pasteur)

  • M. Besson

    (Institut Pasteur
    Université Paris-Sud)

  • B. P. Guiard

    (Université Paris-Sud)

  • J.-P. Guilloux

    (Université Paris-Sud)

  • A. Evrard

    (Institut Pasteur)

  • P. Cazala

    (Université de Bordeaux-I)

  • A. Cormier

    (Institut Pasteur)

  • M. Mameli-Engvall

    (Institut Pasteur)

  • N. Dufour

    (CNRS-UMR 7091, Hôpital de la Pitié-Salpêtrière
    Service Hospitalier Frédéric Joliot)

  • I. Cloëz-Tayarani

    (Institut Pasteur)

  • A.-P. Bemelmans

    (CNRS-UMR 7091, Hôpital de la Pitié-Salpêtrière
    Hôpital Ophtalmique Jules Gonin)

  • J. Mallet

    (CNRS-UMR 7091, Hôpital de la Pitié-Salpêtrière)

  • A. M. Gardier

    (Université Paris-Sud)

  • V. David

    (Université de Bordeaux-I)

  • P. Faure

    (Institut Pasteur)

  • S. Granon

    (Institut Pasteur)

  • J.-P. Changeux

    (Institut Pasteur)

Abstract

The two sides of nicotine The bad news, nicotine addiction has caused the deaths of millions from smoking-related diseases. The good news, nicotine can enhance cognitive performance. In an attempt to disentangle the brain networks that mediate nicotine reward and relevant cognitive functions, Maskos et al. have developed an injectable lentiviral vector that delivers functional nicotinic acetylcholine receptors to defined regions of the mouse brain. The technique was used to generate mice that express nicotinic receptors exclusively in the midbrain ventral tegmental area, the VTA, which contains dopamine reward neurons and is associated with the response to drugs of abuse. The experiment showed that these receptors in the VTA are sufficient for all behavioural and physiological phenomena associated with nicotine dependence. And they are also involved in the higher brain or ‘cognitive’ functions in the mouse. Nicotine's ‘good’ and ‘bad’ sides are, it seems, intimately entangled and originate from a phylogenetically ancient part of the brain.

Suggested Citation

  • U. Maskos & B. E. Molles & S. Pons & M. Besson & B. P. Guiard & J.-P. Guilloux & A. Evrard & P. Cazala & A. Cormier & M. Mameli-Engvall & N. Dufour & I. Cloëz-Tayarani & A.-P. Bemelmans & J. Mallet & , 2005. "Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors," Nature, Nature, vol. 436(7047), pages 103-107, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7047:d:10.1038_nature03694
    DOI: 10.1038/nature03694
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    Cited by:

    1. A. Sofia F. Oliveira & Giovanni Ciccotti & Shozeb Haider & Adrian J. Mulholland, 2021. "Dynamical nonequilibrium molecular dynamics reveals the structural basis for allostery and signal propagation in biomolecular systems," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 94(7), pages 1-12, July.
    2. Julie Routhier & Stéphanie Pons & Mohamed Lamine Freidja & Véronique Dalstein & Jérôme Cutrona & Antoine Jonquet & Nathalie Lalun & Jean-Claude Mérol & Mark Lathrop & Jerry A. Stitzel & Gwenola Kervoa, 2021. "An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Nicolas Maubourguet & Annick Lesne & Jean-Pierre Changeux & Uwe Maskos & Philippe Faure, 2008. "Behavioral Sequence Analysis Reveals a Novel Role for ß2* Nicotinic Receptors in Exploration," PLOS Computational Biology, Public Library of Science, vol. 4(11), pages 1-12, November.

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