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ATP is a mediator of chemosensory transduction in the central nervous system

Author

Listed:
  • Alexander V. Gourine

    (Royal Free and University College London Medical School)

  • Enrique Llaudet

    (University of Warwick)

  • Nicholas Dale

    (University of Warwick)

  • K. Michael Spyer

    (Royal Free and University College London Medical School)

Abstract

Central casting ATP, the simple and evolutionarily ancient molecule ubiquitous in animals and plants as ‘portable energy’, is known to act in the peripheral nervous system, stimulating neurons in response to pain, touch and heat. Now a similar function for ATP has been discovered in the brain, where it is released from chemosensitive structures when the CO2 level in the blood is high and some serious breathing is required.

Suggested Citation

  • Alexander V. Gourine & Enrique Llaudet & Nicholas Dale & K. Michael Spyer, 2005. "ATP is a mediator of chemosensory transduction in the central nervous system," Nature, Nature, vol. 436(7047), pages 108-111, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7047:d:10.1038_nature03690
    DOI: 10.1038/nature03690
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    Cited by:

    1. Daniel S. Kluger & Carina Forster & Omid Abbasi & Nikos Chalas & Arno Villringer & Joachim Gross, 2023. "Modulatory dynamics of periodic and aperiodic activity in respiration-brain coupling," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Liza J. Severs & Nicholas E. Bush & Lely A. Quina & Skyler Hidalgo-Andrade & Nicholas J. Burgraff & Tatiana Dashevskiy & Andy Y. Shih & Nathan A. Baertsch & Jan-Marino Ramirez, 2023. "Purinergic signaling mediates neuroglial interactions to modulate sighs," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Patrick S. Hosford & Jack A. Wells & Shereen Nizari & Isabel N. Christie & Shefeeq M. Theparambil & Pablo A. Castro & Anna Hadjihambi & L. Felipe Barros & Iván Ruminot & Mark F. Lythgoe & Alexander V., 2022. "CO2 signaling mediates neurovascular coupling in the cerebral cortex," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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