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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

Author

Listed:
  • Levi A. Garraway

    (Dana-Farber Cancer Institute
    Brigham and Women's Hospital, Harvard Medical School)

  • Hans R. Widlund

    (Dana-Farber Cancer Institute)

  • Mark A. Rubin

    (Brigham and Women's Hospital and Harvard Medical School
    Brigham and Women's Hospital, Harvard Medical School)

  • Gad Getz

    (The Broad Institute of Harvard and MIT)

  • Aaron J. Berger

    (Yale University School of Medicine)

  • Sridhar Ramaswamy

    (The Broad Institute of Harvard and MIT
    Massachusetts General Hospital Center for Cancer Research and Department of Medicine)

  • Rameen Beroukhim

    (Dana-Farber Cancer Institute
    Brigham and Women's Hospital, Harvard Medical School)

  • Danny A. Milner

    (Brigham and Women's Hospital and Harvard Medical School
    Brigham and Women's Hospital, Harvard Medical School)

  • Scott R. Granter

    (Brigham and Women's Hospital and Harvard Medical School)

  • Jinyan Du

    (Dana-Farber Cancer Institute
    The Broad Institute of Harvard and MIT)

  • Charles Lee

    (Brigham and Women's Hospital and Harvard Medical School
    Brigham and Women's Hospital, Harvard Medical School)

  • Stephan N. Wagner

    (Medical University of Vienna
    Austrian Academy of Sciences)

  • Cheng Li

    (Dana-Farber Cancer Institute
    677 Huntington Avenue)

  • Todd R. Golub

    (Dana-Farber Cancer Institute
    Brigham and Women's Hospital, Harvard Medical School
    The Broad Institute of Harvard and MIT)

  • David L. Rimm

    (Yale University School of Medicine)

  • Matthew L. Meyerson

    (Dana-Farber Cancer Institute
    Brigham and Women's Hospital and Harvard Medical School
    The Broad Institute of Harvard and MIT)

  • David E. Fisher

    (Dana-Farber Cancer Institute
    Brigham and Women's Hospital, Harvard Medical School)

  • William R. Sellers

    (Dana-Farber Cancer Institute
    Brigham and Women's Hospital and Harvard Medical School
    Brigham and Women's Hospital, Harvard Medical School
    The Broad Institute of Harvard and MIT)

Abstract

Melanoma target Analysis of pharmacological and genetic data from the US National Cancer Institute's NCI60 collection of cancer cell lines has identified a novel DNA amplification event in human melanomas. It alters MITF gene expression to promote melanoma formation, probably in cooperation with mutated BRAF, another key melanoma gene. Amplification of MITF may also help melanoma cells resist destruction by drugs. This work identifies MITF itself as a possible drug target in melanoma, and may encourage future genomics efforts to identify genetic alterations in other cancers.

Suggested Citation

  • Levi A. Garraway & Hans R. Widlund & Mark A. Rubin & Gad Getz & Aaron J. Berger & Sridhar Ramaswamy & Rameen Beroukhim & Danny A. Milner & Scott R. Granter & Jinyan Du & Charles Lee & Stephan N. Wagne, 2005. "Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma," Nature, Nature, vol. 436(7047), pages 117-122, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7047:d:10.1038_nature03664
    DOI: 10.1038/nature03664
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    Citations

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    Cited by:

    1. Barry R Zeeberg & William Reinhold & René Snajder & Gerhard G Thallinger & John N Weinstein & Kurt W Kohn & Yves Pommier, 2012. "Functional Categories Associated with Clusters of Genes That Are Co-Expressed across the NCI-60 Cancer Cell Lines," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-10, January.
    2. Chuanyuan Wei & Wei Sun & Kangjie Shen & Jingqin Zhong & Wanlin Liu & Zixu Gao & Yu Xu & Lu Wang & Tu Hu & Ming Ren & Yinlam Li & Yu Zhu & Shaoluan Zheng & Ming Zhu & Rongkui Luo & Yanwen Yang & Yingy, 2023. "Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Miles C. Andrews & Junna Oba & Chang-Jiun Wu & Haifeng Zhu & Tatiana Karpinets & Caitlin A. Creasy & Marie-Andrée Forget & Xiaoxing Yu & Xingzhi Song & Xizeng Mao & A. Gordon Robertson & Gabriele Roma, 2022. "Multi-modal molecular programs regulate melanoma cell state," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Xiao Chen & Yinglu Li & Fang Zhu & Xinjing Xu & Brian Estrella & Manuel A. Pazos & John T. McGuire & Dimitris Karagiannis & Varun Sahu & Mustafo Mustafokulov & Claudio Scuoppo & Francisco J. Sánchez-R, 2023. "Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Pakavarin Louphrasitthiphol & Alessia Loffreda & Vivian Pogenberg & Sarah Picaud & Alexander Schepsky & Hans Friedrichsen & Zhiqiang Zeng & Anahita Lashgari & Benjamin Thomas & E. Elizabeth Patton & M, 2023. "Acetylation reprograms MITF target selectivity and residence time," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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