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Global histone modification patterns predict risk of prostate cancer recurrence

Author

Listed:
  • David B. Seligson

    (University of California)

  • Steve Horvath

    (University of California
    University of California)

  • Tao Shi

    (University of California
    University of California)

  • Hong Yu

    (University of California)

  • Sheila Tze

    (University of California)

  • Michael Grunstein

    (University of California)

  • Siavash K. Kurdistani

    (University of California)

Abstract

Histones in cancer Reports of altered epigenetic histone modifications in cancer cells have focused on individual gene promoters and so far none of these changes has been related to clinical outcome. Now aberrations of ‘global’ histone modification have been observed in prostate tumour patients. These do relate to clinical outcome, and suggest a useful means of prognosis.

Suggested Citation

  • David B. Seligson & Steve Horvath & Tao Shi & Hong Yu & Sheila Tze & Michael Grunstein & Siavash K. Kurdistani, 2005. "Global histone modification patterns predict risk of prostate cancer recurrence," Nature, Nature, vol. 435(7046), pages 1262-1266, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7046:d:10.1038_nature03672
    DOI: 10.1038/nature03672
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    Cited by:

    1. Claudia Bühnemann & Simon Li & Haiyue Yu & Harriet Branford White & Karl L Schäfer & Antonio Llombart-Bosch & Isidro Machado & Piero Picci & Pancras C W Hogendoorn & Nicholas A Athanasou & J Alison No, 2014. "Quantification of the Heterogeneity of Prognostic Cellular Biomarkers in Ewing Sarcoma Using Automated Image and Random Survival Forest Analysis," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-14, September.

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