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An endocannabinoid mechanism for stress-induced analgesia

Author

Listed:
  • Andrea G. Hohmann

    (The University of Georgia)

  • Richard L. Suplita

    (The University of Georgia)

  • Nathan M. Bolton

    (The University of Georgia)

  • Mark H. Neely

    (The University of Georgia)

  • Darren Fegley

    (University of California)

  • Regina Mangieri

    (University of California)

  • Jocelyn F. Krey

    (Brown University)

  • J. Michael Walker

    (Brown University)

  • Philip V. Holmes

    (The University of Georgia)

  • Jonathon D. Crystal

    (The University of Georgia)

  • Andrea Duranti

    (University of Urbino Carlo Bo)

  • Andrea Tontini

    (University of Urbino Carlo Bo)

  • Marco Mor

    (University of Parma)

  • Giorgio Tarzia

    (University of Urbino Carlo Bo)

  • Daniele Piomelli

    (University of California)

Abstract

Stress cancelling Stress activates the neural systems that inhibit the sensation of pain, inducing natural analgesia. Some of these pathways involve natural opiates but now an endocannabinoid-based equivalent has been found. The enzymes that break up these natural marijuana-like compounds may be important therapeutic targets for stress-related disorders.

Suggested Citation

  • Andrea G. Hohmann & Richard L. Suplita & Nathan M. Bolton & Mark H. Neely & Darren Fegley & Regina Mangieri & Jocelyn F. Krey & J. Michael Walker & Philip V. Holmes & Jonathon D. Crystal & Andrea Dura, 2005. "An endocannabinoid mechanism for stress-induced analgesia," Nature, Nature, vol. 435(7045), pages 1108-1112, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7045:d:10.1038_nature03658
    DOI: 10.1038/nature03658
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    Cited by:

    1. Ming Jiang & Mirjam C. W. Huizenga & Jonah L. Wirt & Janos Paloczi & Avand Amedi & Richard J. B. H. N. Berg & Joerg Benz & Ludovic Collin & Hui Deng & Xinyu Di & Wouter F. Driever & Bogdan I. Florea &, 2023. "A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Stamatis Mourtakos & Georgia Vassiliou & Konstantinos Kontoangelos & Anastassios Philippou & Elias Tzavellas & José Francisco Tornero-Aguilera & Vicente Javier Clemente-Suárez & Charalabos Papageorgio, 2021. "Endocannabinoids and Heart Rate Variability Alterations after Exposure to Prolonged Intensive Physical Exercise of the Hellenic Navy SEALs," IJERPH, MDPI, vol. 19(1), pages 1-10, December.

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