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The initiation of liver development is dependent on Foxa transcription factors

Author

Listed:
  • Catherine S. Lee

    (Department of Genetics)

  • Joshua R. Friedman

    (Department of Genetics
    University of Pennsylvania School of Medicine)

  • James T. Fulmer

    (Department of Genetics)

  • Klaus H. Kaestner

    (Department of Genetics)

Abstract

Liver a little Foxa1 and Foxa2 regulatory proteins have been identified as essential for the specification of the cells that form the liver in the vertebrate embryo. Mouse embryos lacking these proteins are essentially liver-less, with no liver bud in the foregut endoderm. The Foxa genetic system may prove to be a useful model for the study of the molecular control of organogenesis in general, since as well as the liver, this part of the embryo forms the lungs, thyroid and pancreas.

Suggested Citation

  • Catherine S. Lee & Joshua R. Friedman & James T. Fulmer & Klaus H. Kaestner, 2005. "The initiation of liver development is dependent on Foxa transcription factors," Nature, Nature, vol. 435(7044), pages 944-947, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7044:d:10.1038_nature03649
    DOI: 10.1038/nature03649
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    Cited by:

    1. Grégoire Vernaz & Milan Malinsky & Hannes Svardal & Mingliu Du & Alexandra M. Tyers & M. Emília Santos & Richard Durbin & Martin J. Genner & George F. Turner & Eric A. Miska, 2021. "Mapping epigenetic divergence in the massive radiation of Lake Malawi cichlid fishes," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Ryan J. Geusz & Allen Wang & Dieter K. Lam & Nicholas K. Vinckier & Konstantinos-Dionysios Alysandratos & David A. Roberts & Jinzhao Wang & Samy Kefalopoulou & Araceli Ramirez & Yunjiang Qiu & Joshua , 2021. "Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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