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A Pax3/Pax7-dependent population of skeletal muscle progenitor cells

Author

Listed:
  • Frédéric Relaix

    (Pasteur Institute)

  • Didier Rocancourt

    (Pasteur Institute)

  • Ahmed Mansouri

    (Max-Planck Institute for Biophysical Chemistry)

  • Margaret Buckingham

    (Pasteur Institute)

Abstract

Muscle building routine A new population of stem cells, present in skeletal muscle, has been identified in two independent studies. The cells are important in the formation of skeletal muscle in the embryo and fetus. The origin of early embryonic muscle cells is well understood, but less is known about the later stages, where progenitor cells in the muscle mass continuously form new cells in the fetus. Relaix et al. identify cells in mice that continue to proliferate in the trunk and limbs during development. These cells express the transcription factors Pax3 and Pax7, the absence of which causes later muscle development to fail. Gros et al. trace lineage in the chick to show that the origin of this cell population is in a region of the embryo called the somite, and that these cells give rise to satellite cells — the committed stem cells of adult skeletal muscle. Greater understanding of the origin of muscle cells may help in developing therapies to combat muscle disease.

Suggested Citation

  • Frédéric Relaix & Didier Rocancourt & Ahmed Mansouri & Margaret Buckingham, 2005. "A Pax3/Pax7-dependent population of skeletal muscle progenitor cells," Nature, Nature, vol. 435(7044), pages 948-953, June.
  • Handle: RePEc:nat:nature:v:435:y:2005:i:7044:d:10.1038_nature03594
    DOI: 10.1038/nature03594
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    Cited by:

    1. Matthieu Dos Santos & Akansha M. Shah & Yichi Zhang & Svetlana Bezprozvannaya & Kenian Chen & Lin Xu & Weichun Lin & John R. McAnally & Rhonda Bassel-Duby & Ning Liu & Eric N. Olson, 2023. "Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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