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Notch signals control the fate of immature progenitor cells in the intestine

Author

Listed:
  • Silvia Fre

    (Massachusetts General Hospital Cancer Center
    Institut Curie-CNRS)

  • Mathilde Huyghe

    (Institut Curie-CNRS)

  • Philippos Mourikis

    (Massachusetts General Hospital Cancer Center
    Université de Paris-Sud XI)

  • Sylvie Robine

    (Institut Curie-CNRS)

  • Daniel Louvard

    (Institut Curie-CNRS)

  • Spyros Artavanis-Tsakonas

    (Massachusetts General Hospital Cancer Center
    Collège de France)

Abstract

Alzheimer's drugs for cancer? Notch genes encode a range of membrane receptors that regulate cell-fate decisions by influencing communication between adjacent cells. Two groups now report the involvement of Notch signals in controlling the fate of intestinal epithelial tissue. In addition, blockade of the Notch pathway with the γ-secretase inhibitor DBZ halted growth of adenomas (polyps) in the small intestine and colon. Various γ-secretase inhibitors are being developed for the treatment of Alzheimer's disease; this new work suggests that they might also be used to treat colorectal cancers.

Suggested Citation

  • Silvia Fre & Mathilde Huyghe & Philippos Mourikis & Sylvie Robine & Daniel Louvard & Spyros Artavanis-Tsakonas, 2005. "Notch signals control the fate of immature progenitor cells in the intestine," Nature, Nature, vol. 435(7044), pages 964-968, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7044:d:10.1038_nature03589
    DOI: 10.1038/nature03589
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    Cited by:

    1. Jina Yun & Simon Hansen & Otto Morris & David T. Madden & Clare Peters Libeu & Arjun J. Kumar & Cameron Wehrfritz & Aaron H. Nile & Yingnan Zhang & Lijuan Zhou & Yuxin Liang & Zora Modrusan & Michelle, 2023. "Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Yuan Liang & Chao Luo & Lijun Sun & Tiange Feng & Wenzhen Yin & Yunhua Zhang & Michael W. Mulholland & Weizhen Zhang & Yue Yin, 2024. "Reduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Sophie K Kay & Heather A Harrington & Sarah Shepherd & Keith Brennan & Trevor Dale & James M Osborne & David J Gavaghan & Helen M Byrne, 2017. "The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt," PLOS Computational Biology, Public Library of Science, vol. 13(2), pages 1-28, February.

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