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c-Myc-regulated microRNAs modulate E2F1 expression

Author

Listed:
  • Kathryn A. O'Donnell

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Erik A. Wentzel

    (Johns Hopkins University School of Medicine)

  • Karen I. Zeller

    (Johns Hopkins University School of Medicine)

  • Chi V. Dang

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Joshua T. Mendell

    (Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

Abstract

MicroRNA in cancer MicroRNAs are regulatory, non-coding RNAs about 22 nucleotides in length: over 200 have been identified in humans, and their functions are beginning to be pinned down. It has been suggested that like other regulatory molecules they might be involved in tumour formation, and three papers in this issue confirm that this is the case. One cluster of microRNAs, known as mir-17–92, is shown to be a potential oncogene by its action in an in vivo model of human B-cell lymphoma. A cluster of microRNAs on human chromosome 13 has been found to be regulated by c-Myc, an important transcription factor that is overexpressed in many human cancers. And analysis of microRNA expression in over 300 individuals shows that microRNA profiles could be of value in cancer diagnosis. There is a global downregulation of microRNA in tumours, and the microRNA profile also reflects the origin and differentiation state of the tumours.

Suggested Citation

  • Kathryn A. O'Donnell & Erik A. Wentzel & Karen I. Zeller & Chi V. Dang & Joshua T. Mendell, 2005. "c-Myc-regulated microRNAs modulate E2F1 expression," Nature, Nature, vol. 435(7043), pages 839-843, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7043:d:10.1038_nature03677
    DOI: 10.1038/nature03677
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    Cited by:

    1. Jian Ma & Lei Li & Bohan Ma & Tianjie Liu & Zixi Wang & Qi Ye & Yunhua Peng & Bin Wang & Yule Chen & Shan Xu & Ke Wang & Fabin Dang & Xinyang Wang & Zixuan Zeng & Yanlin Jian & Zhihua Ren & Yizeng Fan, 2024. "MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. John N. Mariani & Benjamin Mansky & Pernille M. Madsen & Dennis Salinas & Deniz Kesmen & Nguyen P. T. Huynh & Nicholas J. Kuypers & Erin R. Kesel & Janna Bates & Casey Payne & Devin Chandler-Militello, 2024. "Repression of developmental transcription factor networks triggers aging-associated gene expression in human glial progenitor cells," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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