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Design of effective immunotherapy for human autoimmunity

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  • Marc Feldmann

    (Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College School of Medicine, ARC Building)

  • Lawrence Steinman

    (Stanford University)

Abstract

A better understanding of the molecules involved in immune responses has identified many potential targets for the treatment of autoimmune diseases. But although successful therapies have been found for immune disorders in animal studies, few have passed the much harder test of treating human diseases. So far, non-antigen-specific approaches, such as the blocking of tumour-necrosis factor, are achieving some success but the same is not true for antigen-specific approaches. Future therapies will probably include both non-antigen-specific strategies that target cytokines (cell–cell signalling molecules) or block the molecules that stimulate immune responses, and antigen-specific therapies that induce tolerance to self antigens.

Suggested Citation

  • Marc Feldmann & Lawrence Steinman, 2005. "Design of effective immunotherapy for human autoimmunity," Nature, Nature, vol. 435(7042), pages 612-619, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7042:d:10.1038_nature03727
    DOI: 10.1038/nature03727
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    Cited by:

    1. Soodeh Maghsoodi & Naima Mohammadi, 2018. "Qualitative analysis of the process of restoring social esteem by the women with multiple sclerosis," Quality & Quantity: International Journal of Methodology, Springer, vol. 52(6), pages 2557-2575, November.

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