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Vascular respiratory uncoupling increases blood pressure and atherosclerosis

Author

Listed:
  • Carlos Bernal-Mizrachi

    (Metabolism & Lipid Research)

  • Allison C. Gates

    (Metabolism & Lipid Research)

  • Sherry Weng

    (Metabolism & Lipid Research)

  • Takuji Imamura

    (Washington University School of Medicine)

  • Russell H. Knutsen

    (Washington University School of Medicine)

  • Pascual DeSantis

    (Metabolism & Lipid Research)

  • Trey Coleman

    (Metabolism & Lipid Research)

  • R. Reid Townsend

    (Metabolism & Lipid Research)

  • Louis J. Muglia

    (Washington University School of Medicine)

  • Clay F. Semenkovich

    (Metabolism & Lipid Research
    Washington University School of Medicine)

Abstract

Affairs of the blood vessels Coronary heart disease is the most common cause of death in industrialized societies but a clear cause for heart attacks can be identified in only about half of cases. Some of the unexplained cases may be caused by a previously unrecognized mechanism reported this week: inefficient metabolism in the walls of blood vessels. The discovery was made in mice, where respiratory uncoupling in smooth muscle cells, the most common cell type in the artery wall, caused high blood pressure and atherosclerosis. These experimental conditions are like those that result from mitochondrial dysfunction. Pharmacological and nutritional regimes designed to enhance the metabolism in the vasculature may therefore be worth considering as treatments for atherosclerosis.

Suggested Citation

  • Carlos Bernal-Mizrachi & Allison C. Gates & Sherry Weng & Takuji Imamura & Russell H. Knutsen & Pascual DeSantis & Trey Coleman & R. Reid Townsend & Louis J. Muglia & Clay F. Semenkovich, 2005. "Vascular respiratory uncoupling increases blood pressure and atherosclerosis," Nature, Nature, vol. 435(7041), pages 502-506, May.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7041:d:10.1038_nature03527
    DOI: 10.1038/nature03527
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    Cited by:

    1. Yusuke Adachi & Kazutaka Ueda & Seitaro Nomura & Kaoru Ito & Manami Katoh & Mikako Katagiri & Shintaro Yamada & Masaki Hashimoto & Bowen Zhai & Genri Numata & Akira Otani & Munetoshi Hinata & Yuta Hir, 2022. "Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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