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The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours

Author

Listed:
  • Kirsten K. Youngren

    (Case Western Reserve University)

  • Douglas Coveney

    (Duke University)

  • Xiaoning Peng

    (University of Texas, MD Anderson Cancer Center)

  • Chitralekha Bhattacharya

    (University of Texas, MD Anderson Cancer Center)

  • Laura S. Schmidt

    (SAIC-Frederick, Inc.)

  • Michael L. Nickerson

    (NCI Frederick)

  • Bruce T. Lamb

    (Case Western Reserve University)

  • Jian Min Deng

    (University of Texas, MD Anderson Cancer Center)

  • Richard R. Behringer

    (University of Texas, MD Anderson Cancer Center)

  • Blanche Capel

    (Duke University)

  • Edward M. Rubin

    (Lawrence Berkeley National Laboratory)

  • Joseph H. Nadeau

    (Case Western Reserve University
    Case Western Reserve University)

  • Angabin Matin

    (University of Texas, MD Anderson Cancer Center)

Abstract

Testicular cancer The phenotype of Ter testicular germ cell tumour susceptibility gene was first described more than 30 years ago, but it has taken until now for the identity of the gene to be discovered. Ter is a mutation inducing a termination codon on the mouse version of the dead end gene, known from zebrafish embryos. It encodes a protein with an RNA recognition motif, thus implicating RNA biology in testicular tumour development.

Suggested Citation

  • Kirsten K. Youngren & Douglas Coveney & Xiaoning Peng & Chitralekha Bhattacharya & Laura S. Schmidt & Michael L. Nickerson & Bruce T. Lamb & Jian Min Deng & Richard R. Behringer & Blanche Capel & Edwa, 2005. "The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours," Nature, Nature, vol. 435(7040), pages 360-364, May.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7040:d:10.1038_nature03595
    DOI: 10.1038/nature03595
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    Cited by:

    1. Malgorzata M. Duszczyk & Harry Wischnewski & Tamara Kazeeva & Rajika Arora & Fionna E. Loughlin & Christine Schroetter & Ugo Pradère & Jonathan Hall & Constance Ciaudo & Frédéric H.-T. Allain, 2022. "The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Monika Graf & Marta Interlandi & Natalia Moreno & Dörthe Holdhof & Carolin Göbel & Viktoria Melcher & Julius Mertins & Thomas K. Albert & Dennis Kastrati & Amelie Alfert & Till Holsten & Flavia de Far, 2022. "Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Xiaowei Gu & Anna Heinrich & Shu-Yun Li & Tony DeFalco, 2023. "Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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