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Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity

Author

Listed:
  • Li-Ru You

    (Department of Molecular and Cellular Biology)

  • Fu-Jung Lin

    (Department of Molecular and Cellular Biology)

  • Christopher T. Lee

    (Department of Molecular and Cellular Biology)

  • Francesco J. DeMayo

    (Department of Molecular and Cellular Biology
    Baylor College of Medicine)

  • Ming-Jer Tsai

    (Department of Molecular and Cellular Biology
    Baylor College of Medicine)

  • Sophia Y. Tsai

    (Department of Molecular and Cellular Biology
    Baylor College of Medicine)

Abstract

Blood vessels: changing tubes They may both look like small tubes but arteries and veins are in fact anatomically and functionally distinct. Little is known about how vein identity is established, but studies in mouse embryos now show that the transcription factor COUP-TFII specifically marks the venous endothelium and regulates vein identity, thus challenging the current notion that vein identity results from a default pathway. COUP-TFII, a member of the orphan nuclear receptor superfamily, is expressed at high levels in the endothelium of veins but not in arteries. Selective removal of COUP-TFII in the venous endothelium results in activation of the Notch signalling pathway (an arterial marker) and ectopic induction of haematopoietic cell clusters (an arterial function), thus converting the mutant vein to acquire molecular and functional characteristics of an artery.

Suggested Citation

  • Li-Ru You & Fu-Jung Lin & Christopher T. Lee & Francesco J. DeMayo & Ming-Jer Tsai & Sophia Y. Tsai, 2005. "Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity," Nature, Nature, vol. 435(7038), pages 98-104, May.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7038:d:10.1038_nature03511
    DOI: 10.1038/nature03511
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    Cited by:

    1. Thanh Theresa Dinh & Menglan Xiang & Anusha Rajaraman & Yongzhi Wang & Nicole Salazar & Yu Zhu & Walter Roper & Siyeon Rhee & Kevin Brulois & Ed O’Hara & Helena Kiefel & Truc M. Dinh & Yuhan Bi & Dali, 2022. "An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Jacob T. Gafranek & Enrico D’Aniello & Padmapriyadarshini Ravisankar & Kairavee Thakkar & Ronald J. Vagnozzi & Hee-Woong Lim & Nathan Salomonis & Joshua S. Waxman, 2023. "Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Susanne Fleig & Tamar Kapanadze & Jeremiah Bernier-Latmani & Julia K. Lill & Tania Wyss & Jaba Gamrekelashvili & Dustin Kijas & Bin Liu & Anne M. Hüsing & Esther Bovay & Adan Chari Jirmo & Stephan Hal, 2022. "Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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