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Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells

Author

Listed:
  • Qingsheng Li

    (University of Minnesota, MMC 196)

  • Lijie Duan

    (University of Minnesota, MMC 196)

  • Jacob D. Estes

    (University of Minnesota, MMC 196)

  • Zhong-Min Ma

    (University of California)

  • Tracy Rourke

    (University of California)

  • Yichuan Wang

    (University of California)

  • Cavan Reilly

    (University of Minnesota, MMC 303)

  • John Carlis

    (University of Minnesota)

  • Christopher J. Miller

    (University of California
    University of California)

  • Ashley T. Haase

    (University of Minnesota, MMC 196)

Abstract

HIV: stop it in its tracks Two papers in this issue shed light on the early stages of HIV infection. HIV gradually infects and destroys disease-fighting CD4+ T cells in the blood, but also causes loss of CD4+ T cells from mucosal surfaces such as the gut in the initial infection phase. Studies in monkeys infected with simian immunodeficiency virus (SIV) now show that the virus infects and kills memory CD4+ T cells, a T-cell subset responsible for remembering previous infections. Mattapallil et al. found that SIV infects about 50% of memory CD4+ T cells within days of infection. Li et al. show that as well as killing by direct infection, the virus triggers uninfected cells to self-destruct via apoptosis. These findings have clinical implications, stressing the need to reduce viral load at the early stage of infection.

Suggested Citation

  • Qingsheng Li & Lijie Duan & Jacob D. Estes & Zhong-Min Ma & Tracy Rourke & Yichuan Wang & Cavan Reilly & John Carlis & Christopher J. Miller & Ashley T. Haase, 2005. "Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells," Nature, Nature, vol. 434(7037), pages 1148-1152, April.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7037:d:10.1038_nature03513
    DOI: 10.1038/nature03513
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    Cited by:

    1. Borislav Savkovic & Geoff Symonds & John M Murray, 2012. "Stochastic Model of In-Vivo X4 Emergence during HIV Infection: Implications for the CCR5 Inhibitor Maraviroc," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-1, July.
    2. Quentin Le Hingrat & Paola Sette & Cuiling Xu & Andrew R. Rahmberg & Lilas Tarnus & Haritha Annapureddy & Adam Kleinman & Egidio Brocca-Cofano & Ranjit Sivanandham & Sindhuja Sivanandham & Tianyu He &, 2023. "Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Karunasinee Suphaphiphat & Delphine Desjardins & Valérie Lorin & Nastasia Dimant & Kawthar Bouchemal & Laetitia Bossevot & Maxence Galpin-Lebreau & Nathalie Dereuddre-Bosquet & Hugo Mouquet & Roger Gr, 2023. "Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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