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Sexual reproduction between partners of the same mating type in Cryptococcus neoformans

Author

Listed:
  • Xiaorong Lin

    (Duke University Medical Center)

  • Christina M. Hull

    (Duke University Medical Center
    University of Wisconsin)

  • Joseph Heitman

    (Duke University Medical Center)

Abstract

Cryptococcus neoformans is a globally distributed human fungal pathogen that causes life-threatening meningoencephalitis in immunocompromised patients1. It has a defined sexual cycle involving haploid cells of α and a mating types2, yet the vast majority of environmental and clinical isolates are α (ref. 3). Sexual recombination is normally expected to occur between isolates of opposite mating type in organisms with two mating types (or sexes). How sexual reproductive potential can be maintained in an organism with a largely unisexual, nearly clonal population genetic structure is unknown. One clue, however, is that α strains undergo fruiting, a process that resembles sexual mating4 but is thought to be strictly mitotic and asexual. We report here that hallmarks of mating occur during fruiting, including diploidization and meiosis. Pheromone response pathway elements and the key meiotic regulator Dmc1 are required for efficient fruiting. Furthermore, fusion and meiosis can occur between non-isogenic α strains, enabling genetic exchange. These studies reveal how sexual reproduction can occur between partners of the same mating type. These findings have implications for the evolution of microbial pathogens, as well as for parthenogenesis, cell fusion events and transitions between self-fertilizing and outcrossing modes of reproduction observed in both fungi and other kingdoms.

Suggested Citation

  • Xiaorong Lin & Christina M. Hull & Joseph Heitman, 2005. "Sexual reproduction between partners of the same mating type in Cryptococcus neoformans," Nature, Nature, vol. 434(7036), pages 1017-1021, April.
  • Handle: RePEc:nat:nature:v:434:y:2005:i:7036:d:10.1038_nature03448
    DOI: 10.1038/nature03448
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    Cited by:

    1. Pengjie Hu & Hao Ding & Huimin Liu & Yulin Yang & Lei Chen & Guang-Jun He & Weixin Ke & Ping Zhu & Xiuyun Tian & Yan Peng & Zhenghao Shen & Xiaoxia Yao & Changyu Tao & Ence Yang & Guojian Liao & Xiao , 2022. "Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Yen-Wen Wang & Megan C. McKeon & Holly Elmore & Jaqueline Hess & Jacob Golan & Hunter Gage & William Mao & Lynn Harrow & Susana C. Gonçalves & Christina M. Hull & Anne Pringle, 2023. "Invasive Californian death caps develop mushrooms unisexually and bisexually," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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