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Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones

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  • Gordon X. Wang

    (Helen Wills Neuroscience Institute, University of California)

  • Mu-ming Poo

    (Helen Wills Neuroscience Institute, University of California)

Abstract

Axons ‘taste’ their route Two groups this week show that embryonic nerves rely on unexpected sensory devices to guide their growth. The findings help to build a picture of how brains get wired. Ion channels formed by transient receptor potential (TRP) proteins allow adult sensory organs to respond to temperature, mechanical stress or taste. Gordon Wang and Mu-ming Poo have now found TRP channels in an unexpected place: at the tip of embryonic nerves, where the calcium ion currents that they control allow nerves to grow towards or away from guidance molecules. Li et al. show that TRP channels have similar roles in the guidance of growing nerves in the developing cerebellum.

Suggested Citation

  • Gordon X. Wang & Mu-ming Poo, 2005. "Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones," Nature, Nature, vol. 434(7035), pages 898-904, April.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7035:d:10.1038_nature03478
    DOI: 10.1038/nature03478
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    Cited by:

    1. Juan Prada & Manju Sasi & Corinna Martin & Sibylle Jablonka & Thomas Dandekar & Robert Blum, 2018. "An open source tool for automatic spatiotemporal assessment of calcium transients and local ‘signal-close-to-noise’ activity in calcium imaging data," PLOS Computational Biology, Public Library of Science, vol. 14(3), pages 1-34, March.

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