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Wnt signalling in stem cells and cancer

Author

Listed:
  • Tannishtha Reya

    (Duke University Medical Center)

  • Hans Clevers

    (Hubrecht Laboratory)

Abstract

The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues, activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.

Suggested Citation

  • Tannishtha Reya & Hans Clevers, 2005. "Wnt signalling in stem cells and cancer," Nature, Nature, vol. 434(7035), pages 843-850, April.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7035:d:10.1038_nature03319
    DOI: 10.1038/nature03319
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    Cited by:

    1. John cole & Megan A Cole, 2018. "Anti-Aging Medicine for Hair," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 4(4), pages 87-91, May.
    2. Mingming Wu & Xiao Zhang & Weijie Zhang & Yi Shiou Chiou & Wenchang Qian & Xiangtian Liu & Min Zhang & Hong Yan & Shilan Li & Tao Li & Xinghua Han & Pengxu Qian & Suling Liu & Yueyin Pan & Peter E. Lo, 2022. "Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Hongyang Wang & Mariann Bienz & Xiao-Xue Yan & Wenqing Xu, 2023. "Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Yang Liu & Qi Chen & Hyun-Woo Jeong & Bong Ihn Koh & Emma C. Watson & Cong Xu & Martin Stehling & Bin Zhou & Ralf H. Adams, 2022. "A specialized bone marrow microenvironment for fetal haematopoiesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Zvia Agur & Oleg U Kirnasovsky & Genadiy Vasserman & Lilach Tencer-Hershkowicz & Yuri Kogan & Hannah Harrison & Rebecca Lamb & Robert B Clarke, 2011. "Dickkopf1 Regulates Fate Decision and Drives Breast Cancer Stem Cells to Differentiation: An Experimentally Supported Mathematical Model," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-10, September.
    6. Sophie K Kay & Heather A Harrington & Sarah Shepherd & Keith Brennan & Trevor Dale & James M Osborne & David J Gavaghan & Helen M Byrne, 2017. "The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt," PLOS Computational Biology, Public Library of Science, vol. 13(2), pages 1-28, February.

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