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Ipr1 gene mediates innate immunity to tuberculosis

Author

Listed:
  • Hui Pan

    (Harvard School of Public Health)

  • Bo-Shiun Yan

    (Harvard School of Public Health)

  • Mauricio Rojas

    (Harvard School of Public Health
    Universidad de Antioquia)

  • Yuriy V. Shebzukhov

    (Harvard School of Public Health
    Moscow State University)

  • Hongwei Zhou

    (Harvard School of Public Health)

  • Lester Kobzik

    (Harvard School of Public Health)

  • Darren E. Higgins

    (Harvard Medical School)

  • Mark J. Daly

    (Whitehead Institute for Biomedical Research)

  • Barry R. Bloom

    (Harvard School of Public Health)

  • Igor Kramnik

    (Harvard School of Public Health)

Abstract

TB or not TB Only about one in ten individuals infected with Mycobacterium tuberculosis actually develop clinical tuberculosis. Stress, malnutrition, concomitant infections and age all influence susceptibility, but so does genetic host resistance. A gene mediating innate immunity to tuberculosis has now been identified in mice. Expression of the Intracellular pathogen resistance 1 (Ipr1) gene in macrophages limits the multiplication not only of M. tuberculosis but also of Listeria monocytogenes. The closest homologue to Ipr1 protein in humans is the nuclear body protein SP110, so the SP110 gene is a candidate to be tested for a role in tuberculosis susceptibility.

Suggested Citation

  • Hui Pan & Bo-Shiun Yan & Mauricio Rojas & Yuriy V. Shebzukhov & Hongwei Zhou & Lester Kobzik & Darren E. Higgins & Mark J. Daly & Barry R. Bloom & Igor Kramnik, 2005. "Ipr1 gene mediates innate immunity to tuberculosis," Nature, Nature, vol. 434(7034), pages 767-772, April.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7034:d:10.1038_nature03419
    DOI: 10.1038/nature03419
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    Cited by:

    1. Gregory J Fox & Dinh Ngoc Sy & Nguyen Viet Nhung & Bing Yu & Magda K Ellis & Nguyen Van Hung & Nguyen Kim Cuong & Luu Thi Lien & Guy B Marks & Bernadette M Saunders & Warwick J Britton, 2014. "Polymorphisms of SP110 Are Associated with both Pulmonary and Extra-Pulmonary Tuberculosis among the Vietnamese," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-9, July.
    2. Soumya Raychaudhuri & Robert M Plenge & Elizabeth J Rossin & Aylwin C Y Ng & International Schizophrenia Consortium & Shaun M Purcell & Pamela Sklar & Edward M Scolnick & Ramnik J Xavier & David Altsh, 2009. "Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions," PLOS Genetics, Public Library of Science, vol. 5(6), pages 1-15, June.

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