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Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice

Author

Listed:
  • Sabine Steffens

    (University Hospital, Faculty of Medicine)

  • Niels R. Veillard

    (University Hospital, Faculty of Medicine)

  • Claire Arnaud

    (University Hospital, Faculty of Medicine)

  • Graziano Pelli

    (University Hospital, Faculty of Medicine)

  • Fabienne Burger

    (University Hospital, Faculty of Medicine)

  • Christian Staub

    (University Hospital, Faculty of Medicine)

  • Andreas Zimmer

    (University of Bonn)

  • Jean-Louis Frossard

    (University Hospital, Faculty of Medicine)

  • François Mach

    (University Hospital, Faculty of Medicine)

Abstract

Cardiovascular action of THC The immunosuppressive and anti-inflammatory effects of cannabinoids are well documented, and pre-clinical studies provide the rationale for their use to treat autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. Atherosclerosis is now recognized as a chronic inflammatory disease of the large arteries, so it made sense to test the effects of the cannabinoid THC in a mouse atherosclerosis model. Oral administration of THC does indeed have a beneficial effect on established atherosclerosis in mice, at a surprisingly low dose, suggesting a novel use of this drug in cardiovascular diseases.

Suggested Citation

  • Sabine Steffens & Niels R. Veillard & Claire Arnaud & Graziano Pelli & Fabienne Burger & Christian Staub & Andreas Zimmer & Jean-Louis Frossard & François Mach, 2005. "Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice," Nature, Nature, vol. 434(7034), pages 782-786, April.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7034:d:10.1038_nature03389
    DOI: 10.1038/nature03389
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    Cited by:

    1. L. Landa & A. Sulcova & P. Gbelec, 2016. "The use of cannabinoids in animals and therapeutic implications for veterinary medicine: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 61(3), pages 111-122.

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