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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Author

Listed:
  • Heather Stanton

    (University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital)

  • Fraser M. Rogerson

    (University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital)

  • Charlotte J. East

    (University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital)

  • Suzanne B. Golub

    (University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital)

  • Kate E. Lawlor

    (University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital)

  • Clare T. Meeker

    (University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital)

  • Christopher B. Little

    (University of Sydney, Royal North Shore Hospital)

  • Karena Last

    (University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital)

  • Pamela J. Farmer

    (Royal Children's Hospital)

  • Ian K. Campbell

    (The Walter and Eliza Hall Institute of Medical Research)

  • Anne M. Fourie

    (Johnson & Johnson Pharmaceutical Research and Development)

  • Amanda J. Fosang

    (University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital)

Abstract

Osteoarthritis: a joint effort The degradation of cartilage in arthritic joints is associated with loss of aggrecan, a large aggregating proteoglycan, and for many years researchers have sought the ‘aggrecanase’ responsible. Two groups now report success: the enzyme ADAMTS5 (also known as aggrecanase-2) is shown to be the primary aggrecanase in the mouse model of osteoarthritis. More work is needed to tie this in with the disease in humans, but the inhibition of ADAMTS5 now becomes a candidate therapeutic for human osteoarthritis.

Suggested Citation

  • Heather Stanton & Fraser M. Rogerson & Charlotte J. East & Suzanne B. Golub & Kate E. Lawlor & Clare T. Meeker & Christopher B. Little & Karena Last & Pamela J. Farmer & Ian K. Campbell & Anne M. Four, 2005. "ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro," Nature, Nature, vol. 434(7033), pages 648-652, March.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7033:d:10.1038_nature03417
    DOI: 10.1038/nature03417
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    Cited by:

    1. Chenxi Cao & Yuanyuan Shi & Xin Zhang & Qi Li & Jiahao Zhang & Fengyuan Zhao & Qingyang Meng & Wenli Dai & Zhenlong Liu & Wenqiang Yan & Xiaoning Duan & Jiying Zhang & Xin Fu & Jin Cheng & Xiaoqing Hu, 2022. "Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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