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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

Author

Listed:
  • Sonya S. Glasson

    (Wyeth Research)

  • Roger Askew

    (Wyeth Research)

  • Barbara Sheppard

    (Wyeth Research)

  • Brenda Carito

    (Wyeth Research)

  • Tracey Blanchet

    (Wyeth Research)

  • Hak-Ling Ma

    (Wyeth Research)

  • Carl R. Flannery

    (Wyeth Research)

  • Diane Peluso

    (Wyeth Research)

  • Kim Kanki

    (Wyeth Research)

  • Zhiyong Yang

    (Wyeth Research)

  • Manas K. Majumdar

    (Wyeth Research)

  • Elisabeth A. Morris

    (Wyeth Research)

Abstract

Osteoarthritis: a joint effort The degradation of cartilage in arthritic joints is associated with loss of aggrecan, a large aggregating proteoglycan, and for many years researchers have sought the ‘aggrecanase’ responsible. Two groups now report success: the enzyme ADAMTS5 (also known as aggrecanase-2) is shown to be the primary aggrecanase in the mouse model of osteoarthritis. More work is needed to tie this in with the disease in humans, but the inhibition of ADAMTS5 now becomes a candidate therapeutic for human osteoarthritis.

Suggested Citation

  • Sonya S. Glasson & Roger Askew & Barbara Sheppard & Brenda Carito & Tracey Blanchet & Hak-Ling Ma & Carl R. Flannery & Diane Peluso & Kim Kanki & Zhiyong Yang & Manas K. Majumdar & Elisabeth A. Morris, 2005. "Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis," Nature, Nature, vol. 434(7033), pages 644-648, March.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7033:d:10.1038_nature03369
    DOI: 10.1038/nature03369
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    Cited by:

    1. Cornelis P L Paul & Tom Schoorl & Hendrik A Zuiderbaan & Behrouz Zandieh Doulabi & Albert J van der Veen & Peter M van de Ven & Theo H Smit & Barend J van Royen & Marco N Helder & Margriet G Mullender, 2013. "Dynamic and Static Overloading Induce Early Degenerative Processes in Caprine Lumbar Intervertebral Discs," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-13, April.

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