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Recognition of bacterial glycosphingolipids by natural killer T cells

Author

Listed:
  • Yuki Kinjo

    (La Jolla Institute for Allergy and Immunology, San Diego)

  • Douglass Wu

    (The Scripps Research Institute)

  • Gisen Kim

    (La Jolla Institute for Allergy and Immunology, San Diego)

  • Guo-Wen Xing

    (The Scripps Research Institute)

  • Michael A. Poles

    (New York University School of Medicine
    The Rockefeller University)

  • David D. Ho

    (The Rockefeller University)

  • Moriya Tsuji

    (The Rockefeller University
    New York University School of Medicine)

  • Kazuyoshi Kawahara

    (The Kitasato Institute
    Kanto Gakuin University)

  • Chi-Huey Wong

    (The Scripps Research Institute)

  • Mitchell Kronenberg

    (La Jolla Institute for Allergy and Immunology, San Diego)

Abstract

Natural killer T (NKT) cells constitute a highly conserved T lymphocyte subpopulation that has the potential to regulate many types of immune responses through the rapid secretion of cytokines1,2. NKT cells recognize glycolipids presented by CD1d, a class I-like antigen-presenting molecule. They have an invariant T-cell antigen receptor (TCR) α-chain, but whether this invariant TCR recognizes microbial antigens is still controversial. Here we show that most mouse and human NKT cells recognize glycosphingolipids from Sphingomonas, Gram-negative bacteria that do not contain lipopolysaccharide3,4,5. NKT cells are activated in vivo after exposure to these bacterial antigens or bacteria, and mice that lack NKT cells have a marked defect in the clearance of Sphingomonas from the liver. These data suggest that NKT cells are T lymphocytes that provide an innate-type immune response to certain microorganisms through recognition by their antigen receptor, and that they might be useful in providing protection from bacteria that cannot be detected by pattern recognition receptors such as Toll-like receptor 4.

Suggested Citation

  • Yuki Kinjo & Douglass Wu & Gisen Kim & Guo-Wen Xing & Michael A. Poles & David D. Ho & Moriya Tsuji & Kazuyoshi Kawahara & Chi-Huey Wong & Mitchell Kronenberg, 2005. "Recognition of bacterial glycosphingolipids by natural killer T cells," Nature, Nature, vol. 434(7032), pages 520-525, March.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7032:d:10.1038_nature03407
    DOI: 10.1038/nature03407
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    Cited by:

    1. Norimasa Iwanami & Andreas S. Richter & Katarzyna Sikora & Thomas Boehm, 2023. "Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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