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Leptin regulation of bone resorption by the sympathetic nervous system and CART

Author

Listed:
  • Florent Elefteriou

    (Department of Molecular and Human Genetics
    Bone Disease Program of Texas
    Baylor College of Medicine)

  • Jong Deok Ahn

    (Department of Molecular and Human Genetics
    Bone Disease Program of Texas)

  • Shu Takeda

    (Department of Molecular and Human Genetics
    Bone Disease Program of Texas
    Department of Orthopedics
    Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone)

  • Michael Starbuck

    (Department of Molecular and Human Genetics
    Bone Disease Program of Texas)

  • Xiangli Yang

    (Department of Molecular and Human Genetics
    Bone Disease Program of Texas)

  • Xiuyun Liu

    (Department of Molecular and Human Genetics
    Bone Disease Program of Texas)

  • Hisataka Kondo

    (Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone
    Tokyo Medical and Dental University)

  • William G. Richards

    (Amgen Inc., Neuroscience)

  • Tony W. Bannon

    (Amgen Inc., Neuroscience)

  • Masaki Noda

    (Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone
    Tokyo Medical and Dental University)

  • Karine Clement

    (INSERM Avenir team–University Paris 6
    CHRU Pitié Salpétrière, Hôtel-Dieu Nutrition Department)

  • Christian Vaisse

    (University of California San Francisco)

  • Gerard Karsenty

    (Department of Molecular and Human Genetics
    Bone Disease Program of Texas
    Baylor College of Medicine)

Abstract

Leptin link to osteoporosis Bone structure and function are maintained by bone remodelling, a balance of bone resorption by osteoclasts and bone formation by osteoblasts. New work in mice suggests that leptin, best known as a hormone regulating body weight, may play a major role in striking this balance. In one pathway, leptin stimulation of sympathetic neurons promotes differentiation of osteoclasts (and resorption) and in the other, a neuropeptide called CART inhibits osteoclast differentiation. Blockade of the leptin-regulated neural pathway might help prevent bone loss in osteoporosis.

Suggested Citation

  • Florent Elefteriou & Jong Deok Ahn & Shu Takeda & Michael Starbuck & Xiangli Yang & Xiuyun Liu & Hisataka Kondo & William G. Richards & Tony W. Bannon & Masaki Noda & Karine Clement & Christian Vaisse, 2005. "Leptin regulation of bone resorption by the sympathetic nervous system and CART," Nature, Nature, vol. 434(7032), pages 514-520, March.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7032:d:10.1038_nature03398
    DOI: 10.1038/nature03398
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    Cited by:

    1. Anna Lubkowska & Monika Chudecka, 2019. "The Effects of Small-Volume Liposuction Surgery of Subcutaneous Adipose Tissue in the Gluteal-Femoral Region on Selected Biochemical Parameters," IJERPH, MDPI, vol. 16(18), pages 1-11, September.

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