IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v433y2005i7028d10.1038_nature03292.html
   My bibliography  Save this article

Pax3 functions at a nodal point in melanocyte stem cell differentiation

Author

Listed:
  • Deborah Lang

    (University of Pennsylvania
    University of Chicago)

  • Min Min Lu

    (University of Pennsylvania)

  • Li Huang

    (University of Pennsylvania)

  • Kurt A. Engleka

    (University of Pennsylvania)

  • Maozhen Zhang

    (University of Pennsylvania)

  • Emily Y. Chu

    (University of Pennsylvania)

  • Shari Lipner

    (Albert Einstein College of Medicine)

  • Arthur Skoultchi

    (Albert Einstein College of Medicine)

  • Sarah E. Millar

    (University of Pennsylvania)

  • Jonathan A. Epstein

    (University of Pennsylvania)

Abstract

Stem cells waiting for the off Adult stem cells have been identified in a large number of organs. They are not ‘totipotent’, but are held in an undifferentiated state that, once released, leads to a limited number of cell fates. The nature of the molecular program maintaining this balance has now been investigated in adult melanocyte cells, revealing Pax3 transcription factor as part of a regulatory circuit for embryonic neural crest development and adult melanocyte stem cell function. It commits a cell to its fate as a melanocyte by inducing another transcription factor, Mitf; at the same time, by competing with Mitf for binding sites, it blocks differentiation of the stem cell. A cell primed in this way can respond rapidly to external stimuli by adopting the route to differentiation. An understanding of this mechanism brings the prospect of harnessing stem cells for tissue regeneration a step closer.

Suggested Citation

  • Deborah Lang & Min Min Lu & Li Huang & Kurt A. Engleka & Maozhen Zhang & Emily Y. Chu & Shari Lipner & Arthur Skoultchi & Sarah E. Millar & Jonathan A. Epstein, 2005. "Pax3 functions at a nodal point in melanocyte stem cell differentiation," Nature, Nature, vol. 433(7028), pages 884-887, February.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7028:d:10.1038_nature03292
    DOI: 10.1038/nature03292
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature03292
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature03292?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Elle Koren & Alona Feldman & Marianna Yusupova & Avihay Kadosh & Egor Sedov & Roi Ankawa & Yahav Yosefzon & Waseem Nasser & Stefanie Gerstberger & Liam B. Kimel & Noa Priselac & Samara Brown & Sam Sha, 2022. "Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:433:y:2005:i:7028:d:10.1038_nature03292. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.