IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v433y2005i7028d10.1038_nature03287.html
   My bibliography  Save this article

Different time courses of learning-related activity in the prefrontal cortex and striatum

Author

Listed:
  • Anitha Pasupathy

    (Massachusetts Institute of Technology)

  • Earl K. Miller

    (Massachusetts Institute of Technology)

Abstract

In two minds... The ability to follow arbitrary associations, such as “stop at red”, is integral to everyday behaviour and the primate brain is quick to learn them. Both the prefrontal complex and the striatum have been implicated in this process, but their respective roles are largely unknown. An experiment in which brain activity in these two areas was recorded while monkeys learned new associations shows that the learning-related changes occur much more quickly in the striatum, but that changes in the prefrontal cortex were more closely related to improved performance of the new task. It is possible that the striatum learns first, then ‘trains’ the prefrontal cortex.

Suggested Citation

  • Anitha Pasupathy & Earl K. Miller, 2005. "Different time courses of learning-related activity in the prefrontal cortex and striatum," Nature, Nature, vol. 433(7028), pages 873-876, February.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7028:d:10.1038_nature03287
    DOI: 10.1038/nature03287
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature03287
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature03287?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Naveen Sendhilnathan & Anna Ipata & Michael E. Goldberg, 2021. "Mid-lateral cerebellar complex spikes encode multiple independent reward-related signals during reinforcement learning," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    2. Francesco Ceccarelli & Lorenzo Ferrucci & Fabrizio Londei & Surabhi Ramawat & Emiliano Brunamonti & Aldo Genovesio, 2023. "Static and dynamic coding in distinct cell types during associative learning in the prefrontal cortex," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Lisa Katharina Pendt & Iris Reuter & Hermann Müller, 2011. "Motor Skill Learning, Retention, and Control Deficits in Parkinson's Disease," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-10, July.
    4. Richard Freund & Marta Favara & Catherine Porter & Jere Behrman, 2024. "Social Protection and Foundational Cognitive Skills during Adolescence: Evidence from a Large Public Works Program," The World Bank Economic Review, World Bank, vol. 38(2), pages 296-318.
    5. Johannes Algermissen & Jennifer C. Swart & René Scheeringa & Roshan Cools & Hanneke E. M. den Ouden, 2024. "Prefrontal signals precede striatal signals for biased credit assignment in motivational learning biases," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    6. Makoto Ito & Kenji Doya, 2015. "Parallel Representation of Value-Based and Finite State-Based Strategies in the Ventral and Dorsal Striatum," PLOS Computational Biology, Public Library of Science, vol. 11(11), pages 1-25, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:433:y:2005:i:7028:d:10.1038_nature03287. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.