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Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Author

Listed:
  • Irina M. Conboy

    (Department of Neurology and Neurological Sciences
    University of California-Berkeley)

  • Michael J. Conboy

    (Department of Neurology and Neurological Sciences)

  • Amy J. Wagers

    (Stanford University School of Medicine
    Joslin Diabetes Center)

  • Eric R. Girma

    (Department of Neurology and Neurological Sciences)

  • Irving L. Weissman

    (Stanford University School of Medicine)

  • Thomas A. Rando

    (Department of Neurology and Neurological Sciences
    VA Palo Alto Health Care System)

Abstract

The regeneration game Tissues of the body regenerate well in young individuals, less so in older individuals. To find out if this decline is irreversible, or subject to factors in the circulation, Conboy et al. joined together the circulatory systems of young and old mice, as a ‘parabiotic’ pair. Strikingly, regenerative properties of aged muscle and liver were rejuvenated by the serum from younger animals. At the same time there was a restoration of young ‘molecular signatures’, involving Notch signalling (in muscle) and cEBPa-mediated cell cycle regulation (in liver). This suggests that stem and progenitor cells retain proliferative potential even when old, and that the ‘young’ pattern of molecular signalling can reactivate tissue regeneration.

Suggested Citation

  • Irina M. Conboy & Michael J. Conboy & Amy J. Wagers & Eric R. Girma & Irving L. Weissman & Thomas A. Rando, 2005. "Rejuvenation of aged progenitor cells by exposure to a young systemic environment," Nature, Nature, vol. 433(7027), pages 760-764, February.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7027:d:10.1038_nature03260
    DOI: 10.1038/nature03260
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    Cited by:

    1. David E. Lee & Lauren K. McKay & Akshay Bareja & Yongwu Li & Alastair Khodabukus & Nenad Bursac & Gregory A. Taylor & Gurpreet S. Baht & James P. White, 2022. "Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Liankui Zhou & Liu Jiang & Lan Li & Chengchuan Ma & Peixue Xia & Wanqiu Ding & Ying Liu, 2024. "A germline-to-soma signal triggers an age-related decline of mitochondrial stress response," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Wenxue Ma & Alejandro Gutierrez & Daniel J Goff & Ifat Geron & Anil Sadarangani & Christina A M Jamieson & Angela C Court & Alice Y Shih & Qingfei Jiang & Christina C Wu & Kang Li & Kristen M Smith & , 2012. "NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-14, June.
    4. Felicia Lazure & Rick Farouni & Korin Sahinyan & Darren M. Blackburn & Aldo Hernández-Corchado & Gabrielle Perron & Tianyuan Lu & Adrien Osakwe & Jiannis Ragoussis & Colin Crist & Theodore J. Perkins , 2023. "Transcriptional reprogramming of skeletal muscle stem cells by the niche environment," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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