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Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages

Author

Listed:
  • Karl-Ludwig Laugwitz

    (Institute of Molecular Medicine)

  • Alessandra Moretti

    (Institute of Molecular Medicine)

  • Jason Lam

    (Institute of Molecular Medicine)

  • Peter Gruber

    (Cardiac Center)

  • Yinhong Chen

    (Institute of Molecular Medicine)

  • Sarah Woodard

    (Institute of Molecular Medicine)

  • Li-Zhu Lin

    (Institute of Molecular Medicine)

  • Chen-Leng Cai

    (Institute of Molecular Medicine)

  • Min Min Lu

    (University of Pennsylvania)

  • Michael Reth

    (Universität Freiburg, Biologie III, Abteilung Molekulare Immunologie)

  • Oleksandr Platoshyn

    (University of California, San Diego, School of Medicine)

  • Jason X.-J. Yuan

    (University of California, San Diego, School of Medicine)

  • Sylvia Evans

    (Institute of Molecular Medicine)

  • Kenneth R. Chien

    (Institute of Molecular Medicine)

Abstract

Stem cell therapy: take heart The field of cardiac stem cell therapy has been something of a minefield. A growth response following the injection of stem cells is notoriously hard to confirm as de novo cardiac myocytes rather than, say, the result of cell fusion. But a paper published this week may move the field on to more solid ground. Laugwitz et al. report the discovery of authentic native cardiac progenitors (cardioblasts) in the postnatal heart, tracking the cells' identity with a marker of a cardiac progenitor field in the embryo (islet-1). The cells were localized in situ in the intact heart, ‘renewed’ by cell culture and purified by a technique based on conditional genetic marking of the lineage: spontaneous differentiation of the cells was clearly documented. These results will raise new hopes that cardiac stem cell therapy will one day become a reality.

Suggested Citation

  • Karl-Ludwig Laugwitz & Alessandra Moretti & Jason Lam & Peter Gruber & Yinhong Chen & Sarah Woodard & Li-Zhu Lin & Chen-Leng Cai & Min Min Lu & Michael Reth & Oleksandr Platoshyn & Jason X.-J. Yuan & , 2005. "Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages," Nature, Nature, vol. 433(7026), pages 647-653, February.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7026:d:10.1038_nature03215
    DOI: 10.1038/nature03215
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    Cited by:

    1. Lu Han & Yongxia Wu & Kun Fang & Sean Sweeney & Ulyss K. Roesner & Melodie Parrish & Khushbu Patel & Tom Walter & Julia Piermattei & Anthony Trimboli & Julia Lefler & Cynthia D. Timmers & Xue-Zhong Yu, 2023. "The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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