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Interaction network containing conserved and essential protein complexes in Escherichia coli

Author

Listed:
  • Gareth Butland

    (University of Toronto)

  • José Manuel Peregrín-Alvarez

    (Hospital for Sick Children)

  • Joyce Li

    (University of Toronto)

  • Wehong Yang

    (University of Toronto)

  • Xiaochun Yang

    (University of Toronto)

  • Veronica Canadien

    (Affinium Pharmaceuticals)

  • Andrei Starostine

    (University of Toronto)

  • Dawn Richards

    (Affinium Pharmaceuticals)

  • Bryan Beattie

    (Affinium Pharmaceuticals)

  • Nevan Krogan

    (University of Toronto)

  • Michael Davey

    (University of Toronto)

  • John Parkinson

    (Hospital for Sick Children
    Department of Biochemistry
    University of Toronto, Medical Sciences Building)

  • Jack Greenblatt

    (University of Toronto
    Affinium Pharmaceuticals
    University of Toronto, Medical Sciences Building)

  • Andrew Emili

    (University of Toronto
    University of Toronto, Medical Sciences Building)

Abstract

Essence of E. coli Proteomic analysis of native protein–protein interactions in E. coli combined with protein mass spectrometry has revealed an interaction network consisting of the proteins essential to bacterial life. The network is highly conserved, providing insight into core bacterial processes, the nature of evolutionary constraints, and suitable new antimicrobial drug targets.

Suggested Citation

  • Gareth Butland & José Manuel Peregrín-Alvarez & Joyce Li & Wehong Yang & Xiaochun Yang & Veronica Canadien & Andrei Starostine & Dawn Richards & Bryan Beattie & Nevan Krogan & Michael Davey & John Par, 2005. "Interaction network containing conserved and essential protein complexes in Escherichia coli," Nature, Nature, vol. 433(7025), pages 531-537, February.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7025:d:10.1038_nature03239
    DOI: 10.1038/nature03239
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    Cited by:

    1. Josh P. Prince & Jani R. Bolla & Gemma L. M. Fisher & Jarno Mäkelä & Marjorie Fournier & Carol V. Robinson & Lidia K. Arciszewska & David J. Sherratt, 2021. "Acyl carrier protein promotes MukBEF action in Escherichia coli chromosome organization-segregation," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Mu Gao & Davi Nakajima An & Jerry M. Parks & Jeffrey Skolnick, 2022. "AF2Complex predicts direct physical interactions in multimeric proteins with deep learning," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Dmitry Sutormin & Alina Galivondzhyan & Olga Musharova & Dmitrii Travin & Anastasiia Rusanova & Kseniya Obraztsova & Sergei Borukhov & Konstantin Severinov, 2022. "Interaction between transcribing RNA polymerase and topoisomerase I prevents R-loop formation in E. coli," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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