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Chemical structure and biological activity of the Caenorhabditis elegans dauer-inducing pheromone

Author

Listed:
  • Pan-Young Jeong

    (Department of Biochemistry and Yonsei Proteome Research Center)

  • Mankil Jung

    (Department of Chemistry)

  • Yong-Hyeon Yim

    (Korea Research Institute of Standards and Science)

  • Heekyeong Kim

    (Department of Chemistry)

  • Moonsoo Park

    (Department of Chemistry)

  • Eunmi Hong

    (Department of Biochemistry and Yonsei Proteome Research Center)

  • Weontae Lee

    (Department of Biochemistry and Yonsei Proteome Research Center)

  • Young Hwan Kim

    (Korea Basic Science Institute)

  • Kun Kim

    (Yonsei University)

  • Young-Ki Paik

    (Department of Biochemistry and Yonsei Proteome Research Center)

Abstract

Dauer consequences The dauer form in the nematode C. elegans is a non-ageing stage of the life cycle conducive to survival in adverse conditions such as food shortage. The properties of the natural dauer-inducing pheromone (‘daumone’) that regulates ageing and development in C. elegans have been studied for many years, but its precise biochemical identity remained unknown. Daumone has now been purified and fully characterized and, as predicted, it is a fatty acid derivative. Natural and chemically synthesized daumones equally induce dauer larva formation. This work could lead to novel antinematodal drugs and is relevant to research into ageing and obesity.

Suggested Citation

  • Pan-Young Jeong & Mankil Jung & Yong-Hyeon Yim & Heekyeong Kim & Moonsoo Park & Eunmi Hong & Weontae Lee & Young Hwan Kim & Kun Kim & Young-Ki Paik, 2005. "Chemical structure and biological activity of the Caenorhabditis elegans dauer-inducing pheromone," Nature, Nature, vol. 433(7025), pages 541-545, February.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7025:d:10.1038_nature03201
    DOI: 10.1038/nature03201
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    Cited by:

    1. Hyunsoo Yim & Daniel T. Choe & J. Alexander Bae & Myung-kyu Choi & Hae-Mook Kang & Ken C. Q. Nguyen & Soungyub Ahn & Sang-kyu Bahn & Heeseung Yang & David H. Hall & Jinseop S. Kim & Junho Lee, 2024. "Comparative connectomics of dauer reveals developmental plasticity," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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