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Structure of human follicle-stimulating hormone in complex with its receptor

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Listed:
  • Qing R. Fan

    (Department of Biochemistry and Molecular Biophysics)

  • Wayne A. Hendrickson

    (Department of Biochemistry and Molecular Biophysics
    Howard Hughes Medical Institute, Columbia University)

Abstract

Follicle-stimulating hormone (FSH) is central to reproduction in mammals. It acts through a G-protein-coupled receptor on the surface of target cells to stimulate testicular and ovarian functions. We present here the 2.9-Å-resolution structure of a partially deglycosylated complex of human FSH bound to the extracellular hormone-binding domain of its receptor (FSHRHB). The hormone is bound in a hand-clasp fashion to an elongated, curved receptor. The buried interface of the complex is large (2,600 Å2) and has a high charge density. Our analysis suggests that all glycoprotein hormones bind to their receptors in this mode and that binding specificity is mediated by key interaction sites involving both the common α- and hormone-specific β-subunits. On binding, FSH undergoes a concerted conformational change that affects protruding loops implicated in receptor activation. The FSH–FSHRHB complexes form dimers in the crystal and at high concentrations in solution. Such dimers may participate in transmembrane signal transduction.

Suggested Citation

  • Qing R. Fan & Wayne A. Hendrickson, 2005. "Structure of human follicle-stimulating hormone in complex with its receptor," Nature, Nature, vol. 433(7023), pages 269-277, January.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7023:d:10.1038_nature03206
    DOI: 10.1038/nature03206
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    Cited by:

    1. Jia Duan & Peiyu Xu & Huibing Zhang & Xiaodong Luan & Jiaqi Yang & Xinheng He & Chunyou Mao & Dan-Dan Shen & Yujie Ji & Xi Cheng & Hualiang Jiang & Yi Jiang & Shuyang Zhang & Yan Zhang & H. Eric Xu, 2023. "Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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