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Natural and engineered nucleic acids as tools to explore biology

Author

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  • Ronald R. Breaker

    (Cellular and Developmental Biology, Yale University)

Abstract

RNA and DNA molecules can form complex, three-dimensional folded structures that have surprisingly sophisticated functions, including catalysing chemical reactions and controlling gene expression. Although natural nucleic acids make occasional use of these advanced functions, the true potential for sophisticated function by these biological polymers is far greater. An important challenge for biochemists is to take RNA and DNA beyond their proven use as polymers that form double-helical structures. Molecular engineers are beginning to harness the power of nucleic acids that form more complex three-dimensional structures, and apply them as tools for exploring biological systems and as therapeutics.

Suggested Citation

  • Ronald R. Breaker, 2004. "Natural and engineered nucleic acids as tools to explore biology," Nature, Nature, vol. 432(7019), pages 838-845, December.
    • Handle: RePEc:nat:nature:v:432:y:2004:i:7019:d:10.1038_nature03195
    DOI: 10.1038/nature03195
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    Cited by:

    1. Tongqing Li & Xueying Liu & Haifeng Qian & Sheyu Zhang & Yu Hou & Yuchao Zhang & Guoyan Luo & Xun Zhu & Yanxin Tao & Mengyang Fan & Hong Wang & Chulin Sha & Ailan Lin & Jingjing Qin & Kedan Gu & Weich, 2024. "Blocker-SELEX: a structure-guided strategy for developing inhibitory aptamers disrupting undruggable transcription factor interactions," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Mária Brunderová & Vojtěch Havlíček & Ján Matyašovský & Radek Pohl & Lenka Poštová Slavětínská & Matouš Krömer & Michal Hocek, 2024. "Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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