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Chemical space and biology

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  • Christopher M. Dobson

    (University of Cambridge)

Abstract

Chemical space — which encompasses all possible small organic molecules, including those present in biological systems — is vast. So vast, in fact, that so far only a tiny fraction of it has been explored. Nevertheless, these explorations have greatly enhanced our understanding of biology, and have led to the development of many of today's drugs. The discovery of new bioactive molecules, facilitated by a deeper understanding of the nature of the regions of chemical space that are relevant to biology, will advance our knowledge of biological processes and lead to new strategies to treat disease.

Suggested Citation

  • Christopher M. Dobson, 2004. "Chemical space and biology," Nature, Nature, vol. 432(7019), pages 824-828, December.
    • Handle: RePEc:nat:nature:v:432:y:2004:i:7019:d:10.1038_nature03192
    DOI: 10.1038/nature03192
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    Cited by:

    1. Jianyuan Deng & Zhibo Yang & Hehe Wang & Iwao Ojima & Dimitris Samaras & Fusheng Wang, 2023. "A systematic study of key elements underlying molecular property prediction," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Hua Yu & Jianxin Chen & Xue Xu & Yan Li & Huihui Zhao & Yupeng Fang & Xiuxiu Li & Wei Zhou & Wei Wang & Yonghua Wang, 2012. "A Systematic Prediction of Multiple Drug-Target Interactions from Chemical, Genomic, and Pharmacological Data," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-14, May.

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