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The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

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  • Ryan T. Phan

    (Columbia University)

  • Riccardo Dalla-Favera

    (Columbia University)

Abstract

The human proto-oncogene BCL6 encodes a BTB/POZ-zinc-finger transcriptional repressor that is necessary for germinal-centre formation and is implicated in the pathogenesis of B-cell lymphoma1,2,3. The precise function of BCL6 in germinal-centre development and lymphomagenesis is unclear because very few direct BCL6 target genes have been identified4,5,6,7. Here we report that BCL6 suppresses the expression of the p53 (also known as tp 53) tumour suppressor gene and modulates DNA damage-induced apoptotic responses in germinal-centre B cells. BCL6 represses p53 transcription by binding two specific DNA sites within the p53 promoter region and, accordingly, p53 expression is absent in germinal-centre B cells where BCL6 is highly expressed. Suppression of BCL6 expression via specific short interfering RNA leads to increased levels of p53 messenger RNA and protein both under basal conditions and in response to DNA damage. Most notably, constitutive expression of BCL6 protects B cell lines from apoptosis induced by DNA damage. These results suggest that an important function of BCL6 is to allow germinal-centre B cells to tolerate the physiological DNA breaks required for immunoglobulin class switch recombination and somatic hypermutation without inducing a p53-dependent apoptotic response. These findings also imply that deregulated BCL6 expression contributes to lymphomagenesis in part by functional inactivation of p53.

Suggested Citation

  • Ryan T. Phan & Riccardo Dalla-Favera, 2004. "The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells," Nature, Nature, vol. 432(7017), pages 635-639, December.
    • Handle: RePEc:nat:nature:v:432:y:2004:i:7017:d:10.1038_nature03147
    DOI: 10.1038/nature03147
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    Cited by:

    1. Marina A. Schapfl & Gina M. LoMastro & Vincent Z. Braun & Maretoshi Hirai & Michelle S. Levine & Eva Kiermaier & Verena Labi & Andrew J. Holland & Andreas Villunger, 2024. "Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Sylvia Hartmann & Claudia Döring & Christina Jakobus & Benjamin Rengstl & Sebastian Newrzela & Thomas Tousseyn & Xavier Sagaert & Maurilio Ponzoni & Fabio Facchetti & Chris de Wolf-Peeters & Christian, 2013. "Nodular Lymphocyte Predominant Hodgkin Lymphoma and T Cell/Histiocyte Rich Large B Cell Lymphoma - Endpoints of a Spectrum of One Disease?," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-10, November.

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