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Tissue repair and stem cell renewal in carcinogenesis

Author

Listed:
  • Philip A. Beachy

    (The Howard Hughes Medical Institute
    The Johns Hopkins University School of Medicine)

  • Sunil S. Karhadkar

    (The Howard Hughes Medical Institute
    The Johns Hopkins University School of Medicine)

  • David M. Berman

    (The Johns Hopkins University School of Medicine
    The Johns Hopkins University School of Medicine
    The Johns Hopkins University School of Medicine)

Abstract

Cancer is increasingly being viewed as a stem cell disease, both in its propagation by a minority of cells with stem-cell-like properties and in its possible derivation from normal tissue stem cells. But stem cell activity is tightly controlled, raising the question of how normal regulation might be subverted in carcinogenesis. The long-known association between cancer and chronic tissue injury, and the more recently appreciated roles of Hedgehog and Wnt signalling pathways in tissue regeneration, stem cell renewal and cancer growth together suggest that carcinogenesis proceeds by misappropriating homeostatic mechanisms that govern tissue repair and stem cell self-renewal.

Suggested Citation

  • Philip A. Beachy & Sunil S. Karhadkar & David M. Berman, 2004. "Tissue repair and stem cell renewal in carcinogenesis," Nature, Nature, vol. 432(7015), pages 324-331, November.
    • Handle: RePEc:nat:nature:v:432:y:2004:i:7015:d:10.1038_nature03100
    DOI: 10.1038/nature03100
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    Cited by:

    1. Octavio Martínez & M Humberto Reyes-Valdés & Luis Herrera-Estrella, 2010. "Cancer Reduces Transcriptome Specialization," PLOS ONE, Public Library of Science, vol. 5(5), pages 1-10, May.

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