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Stromal fibroblasts in cancer initiation and progression

Author

Listed:
  • Neil A. Bhowmick

    (Vanderbilt University School of Medicine
    Vanderbilt University School of Medicine
    The Vanderbilt–Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Eric G. Neilson

    (The Vanderbilt–Ingram Cancer Center, Vanderbilt University School of Medicine
    Vanderbilt University School of Medicine)

  • Harold L. Moses

    (Vanderbilt University School of Medicine
    The Vanderbilt–Ingram Cancer Center, Vanderbilt University School of Medicine
    Vanderbilt University School of Medicine)

Abstract

It is widely accepted that the development of carcinoma — the most common form of human cancer — is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.

Suggested Citation

  • Neil A. Bhowmick & Eric G. Neilson & Harold L. Moses, 2004. "Stromal fibroblasts in cancer initiation and progression," Nature, Nature, vol. 432(7015), pages 332-337, November.
    • Handle: RePEc:nat:nature:v:432:y:2004:i:7015:d:10.1038_nature03096
    DOI: 10.1038/nature03096
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    Cited by:

    1. Yingzi Li & Hammad Naveed & Sema Kachalo & Lisa X Xu & Jie Liang, 2012. "Mechanisms of Regulating Cell Topology in Proliferating Epithelia: Impact of Division Plane, Mechanical Forces, and Cell Memory," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-10, August.
    2. Saroj Kumar & Thankaraj Salammal Shabi & Erik Goormaghtigh, 2014. "A FTIR Imaging Characterization of Fibroblasts Stimulated by Various Breast Cancer Cell Lines," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-8, November.
    3. Mengxue Zhou & Jiaxin Wang & Jiaxing Pan & Hui Wang & Lujia Huang & Bo Hou & Yi Lai & Fengyang Wang & Qingxiang Guan & Feng Wang & Zhiai Xu & Haijun Yu, 2023. "Nanovesicles loaded with a TGF-β receptor 1 inhibitor overcome immune resistance to potentiate cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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