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G1 cell-cycle control and cancer

Author

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  • Joan Massagué

    (Cancer Biology and Genetics Program, and Howard Hughes Medical Institute, Box 116, Memorial Sloan Kettering Cancer Center)

Abstract

Before replicating DNA during their reproductive cycle, our cells enter a phase called G1 during which they interpret a flood of signals that influence cell division and cell fate. Mistakes in this process lead to cancer. An increasingly complex and coherent view of G1 signalling networks, which coordinate cell growth, proliferation, stress management and survival, is helping to define the roots of malignancies and shows promise for the development of better cancer therapies.

Suggested Citation

  • Joan Massagué, 2004. "G1 cell-cycle control and cancer," Nature, Nature, vol. 432(7015), pages 298-306, November.
    • Handle: RePEc:nat:nature:v:432:y:2004:i:7015:d:10.1038_nature03094
    DOI: 10.1038/nature03094
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    Cited by:

    1. Nishtha Pandey & P K Vinod, 2018. "Mathematical modelling of reversible transition between quiescence and proliferation," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-15, June.
    2. Jasmin Bartl & Marco Zanini & Flavia Bernardi & Antoine Forget & Lena Blümel & Julie Talbot & Daniel Picard & Nan Qin & Gabriele Cancila & Qingsong Gao & Soumav Nath & Idriss Mahoungou Koumba & Mariet, 2022. "The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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