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A relative signalling model for the formation of a topographic neural map

Author

Listed:
  • Michaël Reber

    (The Salk Institute)

  • Patrick Burrola

    (The Salk Institute)

  • Greg Lemke

    (The Salk Institute)

Abstract

The highly ordered wiring of retinal ganglion cell (RGC) neurons in the eye to their synaptic targets in the superior colliculus of the midbrain has long served as the dominant experimental system for the analysis of topographic neural maps1,2,3. Here we describe a quantitative model for the development of one arm of this map—the wiring of the nasal–temporal axis of the retina to the caudal–rostral axis of the superior colliculus. The model is based on RGC–RGC competition that is governed by comparisons of EphA receptor signalling intensity, which are made using ratios of, rather than absolute differences in, EphA signalling between RGCs4. Molecular genetic experiments, exploiting a combinatorial series of EphA receptor knock-in and knockout mice, confirm the salient predictions of the model, and show that it both describes and predicts topographic mapping.

Suggested Citation

  • Michaël Reber & Patrick Burrola & Greg Lemke, 2004. "A relative signalling model for the formation of a topographic neural map," Nature, Nature, vol. 431(7010), pages 847-853, October.
    • Handle: RePEc:nat:nature:v:431:y:2004:i:7010:d:10.1038_nature02957
    DOI: 10.1038/nature02957
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    Cited by:

    1. David C Sterratt & Daniel Lyngholm & David J Willshaw & Ian D Thompson, 2013. "Standard Anatomical and Visual Space for the Mouse Retina: Computational Reconstruction and Transformation of Flattened Retinae with the Retistruct Package," PLOS Computational Biology, Public Library of Science, vol. 9(2), pages 1-10, February.
    2. Rita Gil & Mafalda Valente & Noam Shemesh, 2024. "Rat superior colliculus encodes the transition between static and dynamic vision modes," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Rotem Aharon & Peter W Janes & Anthony W Burgess & Kais Hamza & Fima Klebaner & Martin Lackmann, 2014. "A Mathematical Model for Eph/Ephrin-Directed Segregation of Intermingled Cells," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-19, December.

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