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Coupled oscillators control morning and evening locomotor behaviour of Drosophila

Author

Listed:
  • Dan Stoleru

    (Brandeis University)

  • Ying Peng

    (Brandeis University)

  • José Agosto

    (Brandeis University)

  • Michael Rosbash

    (Brandeis University)

Abstract

Daily rhythms of physiology and behaviour are precisely timed by an endogenous circadian clock1,2. These include separate bouts of morning and evening activity, characteristic of Drosophila melanogaster and many other taxa, including mammals3,4,5. Whereas multiple oscillators have long been proposed to orchestrate such complex behavioural programmes6, their nature and interplay have remained elusive. By using cell-specific ablation, we show that the timing of morning and evening activity in Drosophila derives from two distinct groups of circadian neurons: morning activity from the ventral lateral neurons that express the neuropeptide PDF, and evening activity from another group of cells, including the dorsal lateral neurons. Although the two oscillators can function autonomously, cell-specific rescue experiments with circadian clock mutants indicate that they are functionally coupled.

Suggested Citation

  • Dan Stoleru & Ying Peng & José Agosto & Michael Rosbash, 2004. "Coupled oscillators control morning and evening locomotor behaviour of Drosophila," Nature, Nature, vol. 431(7010), pages 862-868, October.
    • Handle: RePEc:nat:nature:v:431:y:2004:i:7010:d:10.1038_nature02926
    DOI: 10.1038/nature02926
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    Cited by:

    1. Shahnaz Rahman Lone & Vijay Kumar Sharma, 2011. "Circadian Consequence of Socio-Sexual Interactions in Fruit Flies Drosophila melanogaster," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-12, December.
    2. Esteban J Beckwith & E Axel Gorostiza & Jimena Berni & Carolina Rezával & Agustín Pérez-Santángelo & Alejandro D Nadra & María Fernanda Ceriani, 2013. "Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway," PLOS Biology, Public Library of Science, vol. 11(12), pages 1-15, December.

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