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The role of RNA interference in heterochromatic silencing

Author

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  • Zachary Lippman

    (Watson School of Biological Sciences and Cold Spring Harbor Laboratory)

  • Rob Martienssen

    (Watson School of Biological Sciences and Cold Spring Harbor Laboratory)

Abstract

Soon after its discovery 75 years ago, heterochromatin, a dense chromosomal material, was found to silence genes. But its importance in regulating gene expression was controversial. Long thought to be inert, heterochromatin is now known to give rise to small RNAs, which, by means of RNA interference, direct the modification of proteins and DNA in heterochromatic repeats and transposable elements. Heterochromatin has thus emerged as a key factor in epigenetic regulation of gene expression, chromosome behaviour and evolution.

Suggested Citation

  • Zachary Lippman & Rob Martienssen, 2004. "The role of RNA interference in heterochromatic silencing," Nature, Nature, vol. 431(7006), pages 364-370, September.
    • Handle: RePEc:nat:nature:v:431:y:2004:i:7006:d:10.1038_nature02875
    DOI: 10.1038/nature02875
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    1. Lei Li & Huaihao Yang & Yi Zhao & Qianqian Hu & Xiaotuo Zhang & Ting Jiang & Hua Jiang & Binglian Zheng, 2024. "ARID1 is required to regulate and reinforce H3K9me2 in sperm cells in Arabidopsis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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