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The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

Author

Listed:
  • Thomas Voets

    (Campus Gasthuisberg, KU Leuven)

  • Guy Droogmans

    (Campus Gasthuisberg, KU Leuven)

  • Ulrich Wissenbach

    (Universität des Saarlandes)

  • Annelies Janssens

    (Campus Gasthuisberg, KU Leuven)

  • Veit Flockerzi

    (Universität des Saarlandes)

  • Bernd Nilius

    (Campus Gasthuisberg, KU Leuven)

Abstract

The mammalian sensory system is capable of discriminating thermal stimuli ranging from noxious cold to noxious heat. Principal temperature sensors belong to the TRP cation channel family, but the mechanisms underlying the marked temperature sensitivity of opening and closing (‘gating’) of these channels are unknown. Here we show that temperature sensing is tightly linked to voltage-dependent gating in the cold-sensitive channel TRPM8 and the heat-sensitive channel TRPV1. Both channels are activated upon depolarization, and changes in temperature result in graded shifts of their voltage-dependent activation curves. The chemical agonists menthol (TRPM8) and capsaicin (TRPV1) function as gating modifiers, shifting activation curves towards physiological membrane potentials. Kinetic analysis of gating at different temperatures indicates that temperature sensitivity in TRPM8 and TRPV1 arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Our results suggest a simple unifying principle that explains both cold and heat sensitivity in TRP channels.

Suggested Citation

  • Thomas Voets & Guy Droogmans & Ulrich Wissenbach & Annelies Janssens & Veit Flockerzi & Bernd Nilius, 2004. "The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels," Nature, Nature, vol. 430(7001), pages 748-754, August.
    • Handle: RePEc:nat:nature:v:430:y:2004:i:7001:d:10.1038_nature02732
    DOI: 10.1038/nature02732
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    Cited by:

    1. Erick Olivares & Simón Salgado & Jean Paul Maidana & Gaspar Herrera & Matías Campos & Rodolfo Madrid & Patricio Orio, 2015. "TRPM8-Dependent Dynamic Response in a Mathematical Model of Cold Thermoreceptor," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-17, October.
    2. Cheng Zhao & Yuan Xie & Lizhen Xu & Fan Ye & Ximing Xu & Wei Yang & Fan Yang & Jiangtao Guo, 2022. "Structures of a mammalian TRPM8 in closed state," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Lavanya Moparthi & Viktor Sinica & Vamsi K. Moparthi & Mohamed Kreir & Thibaut Vignane & Milos R. Filipovic & Viktorie Vlachova & Peter M. Zygmunt, 2022. "The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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