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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

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  • Jason G. Wood

    (Harvard Medical School)

  • Blanka Rogina

    (University of Connecticut Health Center)

  • Siva Lavu

    (Harvard Medical School)

  • Konrad Howitz

    (BIOMOL Research Laboratories, Inc.)

  • Stephen L. Helfand

    (University of Connecticut Health Center)

  • Marc Tatar

    (Brown University)

  • David Sinclair

    (Harvard Medical School)

Abstract

Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases2,3. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast4. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction.

Suggested Citation

  • Jason G. Wood & Blanka Rogina & Siva Lavu & Konrad Howitz & Stephen L. Helfand & Marc Tatar & David Sinclair, 2004. "Sirtuin activators mimic caloric restriction and delay ageing in metazoans," Nature, Nature, vol. 430(7000), pages 686-689, August.
    • Handle: RePEc:nat:nature:v:430:y:2004:i:7000:d:10.1038_nature02789
    DOI: 10.1038/nature02789
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    Cited by:

    1. Ulrich Horst & Wei Xu, 2019. "Functional Limit Theorems for Marked Hawkes Point Measures ," Working Papers hal-02443841, HAL.
    2. Diego Calzolari & Stefania Bruschi & Laurence Coquin & Jennifer Schofield & Jacob D Feala & John C Reed & Andrew D McCulloch & Giovanni Paternostro, 2008. "Search Algorithms as a Framework for the Optimization of Drug Combinations," PLOS Computational Biology, Public Library of Science, vol. 4(12), pages 1-14, December.
    3. Horst, Ulrich & Xu, Wei, 2021. "Functional limit theorems for marked Hawkes point measures," Stochastic Processes and their Applications, Elsevier, vol. 134(C), pages 94-131.

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