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Inferences, questions and possibilities in Toll-like receptor signalling

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  • Bruce Beutler

    (The Scripps Research Institute)

Abstract

The Toll-like receptors (TLRs) are the key proteins that allow mammals — whether immunologically naive or experienced — to detect microbes. They lie at the core of our inherited resistance to disease, initiating most of the phenomena that occur in the course of infection. Quasi-infectious stimuli that have been used for decades to study inflammatory mechanisms can activate the TLR family of proteins. And it now seems that many inflammatory processes, both sterile and infectious, may depend on TLR signalling. We are in a good position to apply our understanding of TLR signalling to a range of challenges in immunology and medicine.

Suggested Citation

  • Bruce Beutler, 2004. "Inferences, questions and possibilities in Toll-like receptor signalling," Nature, Nature, vol. 430(6996), pages 257-263, July.
    • Handle: RePEc:nat:nature:v:430:y:2004:i:6996:d:10.1038_nature02761
    DOI: 10.1038/nature02761
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    Cited by:

    1. Xiangyu Wang & Yan Ding & Ran Li & Rujun Zhang & Xuejun Ge & Ruifang Gao & Miao Wang & Yubing Huang & Fang Zhang & Bin Zhao & Wang Liao & Jie Du, 2023. "N6-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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