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PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates

Author

Listed:
  • Xiaowei Lu

    (Howard Hughes Medical Institute)

  • Annette G. M. Borchers

    (Stanford University)

  • Christine Jolicoeur

    (Howard Hughes Medical Institute)

  • Helen Rayburn

    (Howard Hughes Medical Institute)

  • Julie C. Baker

    (Stanford University)

  • Marc Tessier-Lavigne

    (Howard Hughes Medical Institute
    Genentech Inc.)

Abstract

In addition to the apical–basal polarity pathway operating in epithelial cells, a planar cell polarity (PCP) pathway establishes polarity within the plane of epithelial tissues and is conserved from Drosophila to mammals. In Drosophila, a ‘core’ group of PCP genes including frizzled (fz), flamingo/starry night, dishevelled (dsh), Van Gogh/strabismus and prickle, function to regulate wing hair, bristle and ommatidial polarity1,2,3. In vertebrates, the PCP pathway regulates convergent extension movements and neural tube closure3,4,5, as well as the orientation of stereociliary bundles of sensory hair cells in the inner ear6. Here we show that a mutation in the mouse protein tyrosine kinase 7 (PTK7) gene, which encodes an evolutionarily conserved transmembrane protein with tyrosine kinase homology, disrupts neural tube closure and stereociliary bundle orientation, and shows genetic interactions with a mutation in the mouse Van Gogh homologue vangl2. We also show that PTK7 is dynamically localized during hair cell polarization, and that the Xenopus homologue of PTK7 is required for neural convergent extension and neural tube closure. These results identify PTK7 as a novel regulator of PCP in vertebrates.

Suggested Citation

  • Xiaowei Lu & Annette G. M. Borchers & Christine Jolicoeur & Helen Rayburn & Julie C. Baker & Marc Tessier-Lavigne, 2004. "PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates," Nature, Nature, vol. 430(6995), pages 93-98, July.
  • Handle: RePEc:nat:nature:v:430:y:2004:i:6995:d:10.1038_nature02677
    DOI: 10.1038/nature02677
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    Cited by:

    1. Jina Yun & Simon Hansen & Otto Morris & David T. Madden & Clare Peters Libeu & Arjun J. Kumar & Cameron Wehrfritz & Aaron H. Nile & Yingnan Zhang & Lijuan Zhou & Yuxin Liang & Zora Modrusan & Michelle, 2023. "Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Daniel Jun-Kit Hu & Jina Yun & Justin Elstrott & Heinrich Jasper, 2021. "Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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