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Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus

Author

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  • Christoph Schmidt-Hieber

    (Physiologisches Institut der Universität Freiburg)

  • Peter Jonas

    (Physiologisches Institut der Universität Freiburg)

  • Josef Bischofberger

    (Physiologisches Institut der Universität Freiburg)

Abstract

Neural stem cells in various regions of the vertebrate brain continuously generate neurons throughout life1,2,3,4. In the mammalian hippocampus, a region important for spatial and episodic memory5,6, thousands of new granule cells are produced per day7, with the exact number depending on environmental conditions and physical exercise1,8. The survival of these neurons is improved by learning and conversely learning may be promoted by neurogenesis8,9,10. Although it has been suggested that newly generated neurons may have specific properties to facilitate learning2,10,11, the cellular and synaptic mechanisms of plasticity in these neurons are largely unknown. Here we show that young granule cells in the adult hippocampus differ substantially from mature granule cells in both active and passive membrane properties. In young neurons, T-type Ca2+ channels can generate isolated Ca2+ spikes and boost fast Na+ action potentials, contributing to the induction of synaptic plasticity. Associative long-term potentiation can be induced more easily in young neurons than in mature neurons under identical conditions. Thus, newly generated neurons express unique mechanisms to facilitate synaptic plasticity, which may be important for the formation of new memories.

Suggested Citation

  • Christoph Schmidt-Hieber & Peter Jonas & Josef Bischofberger, 2004. "Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus," Nature, Nature, vol. 429(6988), pages 184-187, May.
  • Handle: RePEc:nat:nature:v:429:y:2004:i:6988:d:10.1038_nature02553
    DOI: 10.1038/nature02553
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    Cited by:

    1. Nicola Forte & Serena Boccella & Lea Tunisi & Alba Clara Fernández-Rilo & Roberta Imperatore & Fabio Arturo Iannotti & Maria Risi & Monica Iannotta & Fabiana Piscitelli & Raffaele Capasso & Paolo Giro, 2021. "Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice," Nature Communications, Nature, vol. 12(1), pages 1-20, December.
    2. Mitsuhiko Kawano & Ken Sawada & Shinji Shimodera & Yasuhiro Ogawa & Shinji Kariya & Donna J Lang & Shimpei Inoue & William G Honer, 2015. "Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-14, February.
    3. Thomas Hainmueller & Aurore Cazala & Li-Wen Huang & Marlene Bartos, 2024. "Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Balázs Ujfalussy & Tamás Kiss & Péter Érdi, 2009. "Parallel Computational Subunits in Dentate Granule Cells Generate Multiple Place Fields," PLOS Computational Biology, Public Library of Science, vol. 5(9), pages 1-16, September.
    5. M. Agustina Frechou & Sunaina S. Martin & Kelsey D. McDermott & Evan A. Huaman & Şölen Gökhan & Wolfgang A. Tomé & Ruben Coen-Cagli & J. Tiago Gonçalves, 2024. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Lucas A Mongiat & M Soledad Espósito & Gabriela Lombardi & Alejandro F Schinder, 2009. "Reliable Activation of Immature Neurons in the Adult Hippocampus," PLOS ONE, Public Library of Science, vol. 4(4), pages 1-11, April.

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