IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v429y2004i6988d10.1038_nature02553.html
   My bibliography  Save this article

Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus

Author

Listed:
  • Christoph Schmidt-Hieber

    (Physiologisches Institut der Universität Freiburg)

  • Peter Jonas

    (Physiologisches Institut der Universität Freiburg)

  • Josef Bischofberger

    (Physiologisches Institut der Universität Freiburg)

Abstract

Neural stem cells in various regions of the vertebrate brain continuously generate neurons throughout life1,2,3,4. In the mammalian hippocampus, a region important for spatial and episodic memory5,6, thousands of new granule cells are produced per day7, with the exact number depending on environmental conditions and physical exercise1,8. The survival of these neurons is improved by learning and conversely learning may be promoted by neurogenesis8,9,10. Although it has been suggested that newly generated neurons may have specific properties to facilitate learning2,10,11, the cellular and synaptic mechanisms of plasticity in these neurons are largely unknown. Here we show that young granule cells in the adult hippocampus differ substantially from mature granule cells in both active and passive membrane properties. In young neurons, T-type Ca2+ channels can generate isolated Ca2+ spikes and boost fast Na+ action potentials, contributing to the induction of synaptic plasticity. Associative long-term potentiation can be induced more easily in young neurons than in mature neurons under identical conditions. Thus, newly generated neurons express unique mechanisms to facilitate synaptic plasticity, which may be important for the formation of new memories.

Suggested Citation

  • Christoph Schmidt-Hieber & Peter Jonas & Josef Bischofberger, 2004. "Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus," Nature, Nature, vol. 429(6988), pages 184-187, May.
  • Handle: RePEc:nat:nature:v:429:y:2004:i:6988:d:10.1038_nature02553
    DOI: 10.1038/nature02553
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature02553
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature02553?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Nicola Forte & Serena Boccella & Lea Tunisi & Alba Clara Fernández-Rilo & Roberta Imperatore & Fabio Arturo Iannotti & Maria Risi & Monica Iannotta & Fabiana Piscitelli & Raffaele Capasso & Paolo Giro, 2021. "Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice," Nature Communications, Nature, vol. 12(1), pages 1-20, December.
    2. Thomas Hainmueller & Aurore Cazala & Li-Wen Huang & Marlene Bartos, 2024. "Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Mitsuhiko Kawano & Ken Sawada & Shinji Shimodera & Yasuhiro Ogawa & Shinji Kariya & Donna J Lang & Shimpei Inoue & William G Honer, 2015. "Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-14, February.
    4. Balázs Ujfalussy & Tamás Kiss & Péter Érdi, 2009. "Parallel Computational Subunits in Dentate Granule Cells Generate Multiple Place Fields," PLOS Computational Biology, Public Library of Science, vol. 5(9), pages 1-16, September.
    5. M. Agustina Frechou & Sunaina S. Martin & Kelsey D. McDermott & Evan A. Huaman & Şölen Gökhan & Wolfgang A. Tomé & Ruben Coen-Cagli & J. Tiago Gonçalves, 2024. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Lucas A Mongiat & M Soledad Espósito & Gabriela Lombardi & Alejandro F Schinder, 2009. "Reliable Activation of Immature Neurons in the Adult Hippocampus," PLOS ONE, Public Library of Science, vol. 4(4), pages 1-11, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:429:y:2004:i:6988:d:10.1038_nature02553. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.