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Catch-up growth and obesity in male mice

Author

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  • Susan E. Ozanne

    (University of Cambridge)

  • C. Nicholas Hales

    (University of Cambridge)

Abstract

Poor fetal growth is linked with long-term detrimental effects on health in adulthood1. Here we investigate whether the lifespan of male mice is affected by their growth rate when they were suckling and find that limiting growth during that period not only increases longevity but also protects against the life-shortening effect of an obesity-inducing diet later on. By contrast, we find that lifespan is considerably shortened if the postnatal period of growth is accelerated to make up for reduced growth in utero, and that, in addition, these mice are susceptible to the adverse effects on longevity of an obesity-inducing diet after weaning.

Suggested Citation

  • Susan E. Ozanne & C. Nicholas Hales, 2004. "Catch-up growth and obesity in male mice," Nature, Nature, vol. 427(6973), pages 411-412, January.
    • Handle: RePEc:nat:nature:v:427:y:2004:i:6973:d:10.1038_427411b
    DOI: 10.1038/427411b
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    Cited by:

    1. Shen, Ke & Zeng, Yi, 2014. "Direct and indirect effects of childhood conditions on survival and health among male and female elderly in China," Social Science & Medicine, Elsevier, vol. 119(C), pages 207-214.
    2. Qing Wang & Jay J. Shen, 2016. "Childhood Health Status and Adulthood Cardiovascular Disease Morbidity in Rural China: Are They Related?," IJERPH, MDPI, vol. 13(6), pages 1-10, June.
    3. Meng, Xin & Qian, Nancy, 2006. "The Long Run Health and Economic Consequences of Famine on Survivors: Evidence from China’s Great Famine," IZA Discussion Papers 2471, Institute of Labor Economics (IZA).
    4. Lin, Ming-Jen & Liu, Elaine M., 2014. "Does in utero exposure to Illness matter? The 1918 influenza epidemic in Taiwan as a natural experiment," Journal of Health Economics, Elsevier, vol. 37(C), pages 152-163.
    5. Case, Anne & Fertig, Angela & Paxson, Christina, 2005. "The lasting impact of childhood health and circumstance," Journal of Health Economics, Elsevier, vol. 24(2), pages 365-389, March.
    6. Pascale Chavatte-Palmer & Anne Tarrade & Delphine Rousseau-Ralliard, 2016. "Diet before and during Pregnancy and Offspring Health: The Importance of Animal Models and What Can Be Learned from Them," IJERPH, MDPI, vol. 13(6), pages 1-14, June.
    7. Xin Meng & Nancy Qian, 2009. "The Long Term Consequences of Famine on Survivors: Evidence from a Unique Natural Experiment using China's Great Famine," NBER Working Papers 14917, National Bureau of Economic Research, Inc.
    8. Lin, Ming-Jen & Liu, Elaine M., 2014. "Does in utero exposure to Illness matter? The 1918 influenza epidemic in Taiwan as a natural experiment," Journal of Health Economics, Elsevier, vol. 37(C), pages 152-163.

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